LOCUS       NC_015434              20933 bp    DNA     linear   CON 27-APR-2023
DEFINITION  Micromonospora maris AB-18-032, complete sequence.
ACCESSION   NC_015434
VERSION     NC_015434.1
KEYWORDS    .
SOURCE      Micromonospora maris AB-18-032
  ORGANISM  Micromonospora maris AB-18-032
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP002638.1.
            Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
            Bacteria available from James E.M. Stach (School of Biology Ridley
            Building University of Newcastle, E-mail: jem.stach@ncl.ac.uk).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2023-06-16 18:53:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4913334
            Orig. end    :: 4934267
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20933
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10933]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10933
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..20933
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20933
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="19"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     gene            complement(120..1673)
                     /locus_tag="VAB18032_RS21595"
                     /old_locus_tag="VAB18032_26601"
     CDS             complement(120..1673)
                     /EC_number="4.1.3.27"
                     /GO_function="GO:0004049 - anthranilate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 352.4; E-value:
                     8.3e-107)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014386.1"
                     /locus_tag="VAB18032_RS21595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26601"
                     /product="anthranilate synthase component I"
                     /protein_id="WP_013735048.1"
                     /transl_table=11
                     /translation="MTDGRVSPDETTFTELAARWRVVPVTRRLLADAETPVGVYRKLAG
                     GPGTFLLESAEQGVGSAGLAWARYSFVGVRSSATLVERDGAAAWLGTPPAGLPTTGDPV
                     EVLRATVAALAGPPGDPQGGMPPLTGGMVGYLGYDLIRRFERLPALTEDDLAVPELGMM
                     LATDLVVLDHFDGSAILVANAILPPQDEPGREALVAAAYHHAVGRLDAMTTALSRPIPP
                     MVSTVHRPPVGEVRSRTPDGGYPKAVEAAKEAIRAGECFQIVLAQRFERDTAADPLDVY
                     RVLRTTNPSPYMYLLRFDDFDIVGSSPEAHLKVTIEESGERRALLHPIAGTRPRGATPE
                     ADARLAAELLADPKERAEHVMLVDLGRNDLGRVCRPGTVEVPEFATIERYSHVMHIVST
                     VVGTLREDRTAFDALAATFPAGTLSGAPKVRAMEIIEELEPVRRGLYGGTVGYFGFGGD
                     LDMAIAIRTALMRAGRAYVQAGAGVVADSDPAAEDQETRNKAAAVLAAIAAAETLRAAR
                     "
     gene            complement(1670..2097)
                     /gene="hisI"
                     /locus_tag="VAB18032_RS21600"
                     /pseudo=""
     CDS             complement(1670..2097)
                     /GO_function="GO:0004635 - phosphoribosyl-AMP
                     cyclohydrolase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183495.1"
                     /locus_tag="VAB18032_RS21600"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VPVPDAPVTGAHREGRPRPAARTGRPGSTRRSPPGCAGPPTAWWP
                     PWSVSTTAVRC"
     gene            complement(<2389..2625)
                     /locus_tag="VAB18032_RS32145"
                     /pseudo=""
     CDS             complement(<2389..2625)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037778.2"
                     /locus_tag="VAB18032_RS32145"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIASLGKVASARDADDRLGVRLAAADLARLCPSVLRLANPSVRVV
                     SRRSAFTAALDLPVAPAGYREAMLRCLGLRPGST"
     gene            3206..3937
                     /locus_tag="VAB18032_RS21605"
                     /old_locus_tag="VAB18032_26616"
     CDS             3206..3937
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 174.7; E-value:
                     4e-53)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014388.1"
                     /locus_tag="VAB18032_RS21605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26616"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013735049.1"
                     /transl_table=11
                     /translation="MVDAIAVRGLVVDRGGRRVLDGIDAVVPGGSVTGLLGPSGSGKTT
                     LMRAIVGVQVITAGAVTVLGQPAGSAGLRHRVGYLTQAPSVYADLTVRENARYFATLHG
                     RGADEADRAVADVGLAAAARQLVGNLSGGQRSRASLACVLVGDPELIVLDEPTVGQDPV
                     LRADLWARFHELAAAGTTLLVSSHVMDEAARCDRLLLIRAGRLVADDTPDAVRSAAGVD
                     DLDEAFLRLIRAAETTQAGEA"
     gene            3937..4692
                     /locus_tag="VAB18032_RS21610"
                     /old_locus_tag="VAB18032_26621"
     CDS             3937..4692
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 78.6; E-value: 7.2e-24)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018830540.1"
                     /locus_tag="VAB18032_RS21610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26621"
                     /product="ABC transporter permease"
                     /protein_id="WP_013735050.1"
                     /transl_table=11
                     /translation="MNSRILVATVGRILRQLRHDRRTVALLVVVPTVLLTLVYYMYADQ
                     PSVPGTSSAFDRIALVMLGFFPFIIMFLVTSIAMLRERTSGTLERLLTTPLAKADLLFG
                     YGIAFGLAGAVQATIASAVAYWVFDLHTAGSSGLVIMIAALNAVLAVALGLLCSAFART
                     EFQAVQFMPVVVAPQLLLCGLFVPREQMAGWLQAVSDALPLTYAVEALQEVGAHAEPTA
                     TMWRDVAVVAAVAVLALLLAAATLRRRSS"
     gene            4765..5355
                     /locus_tag="VAB18032_RS21615"
                     /old_locus_tag="VAB18032_26626"
     CDS             4765..5355
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 79.1; E-value: 9.6e-24)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183498.1"
                     /locus_tag="VAB18032_RS21615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26626"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_013735051.1"
                     /transl_table=11
                     /translation="MARRTGRRPGNPATREAILDAARATFGQRGYDGSTIRAIAAAAGV
                     DPALVHHYFGSKDQLFLAAMQAPFDPREVLPAVLAGDRAGLGERIVRTFLSVWDSPAGT
                     AGIAMLRSAVSNEWTARLLREFVTIHVLRPILDHVDVDPAEVPLRGSLLASQLVGLAVM
                     RHVIRLEPIATADPEVLVAAIAPTIGRYLTAPL"
     gene            complement(5356..7125)
                     /locus_tag="VAB18032_RS21620"
                     /old_locus_tag="VAB18032_26631"
     CDS             complement(5356..7125)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 373.3; E-value:
                     3.7e-113)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018730772.1"
                     /locus_tag="VAB18032_RS21620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26631"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013735052.1"
                     /transl_table=11
                     /translation="MNAASERVESTWATLRRGLALSPELRVGLAGTLGLALVYMLGRVA
                     VPVAVQQGIDRGIVGGLDLNALFVVVAVTAAVLVVTTACGYLMMRRLFTVSETALAGVR
                     VRAFRHVHDLSMLHQQSERRGSLVSRVTSDVDQITQFLQWGGVILLVNLGQLAVTTVVM
                     LAYSWQLTLVVFAAFVPAVLVIRLLQRRLAAAYGVVRQRTGALLGAVGESVVGAPVIRA
                     YGIAGRTARRLDQAIDSQRQAQQKAIRISILGSSVGELAAGVALAGVVVVGVLLGADQT
                     LSIGEVTAFLFLVTLFIQPVQIATEVLNEAQNAIAGWRRVLDVLDVSPDVADPGEQGRE
                     LPPGPLDIRFAGVSFAYPNGPTVLHDVSLEIPAKSRVAVVGETGSGKTTFAKLLTRLMD
                     PTQGDVLLSGVPLTDVRFESLRSRVVMVPQDGFLFDATVADNVRFGRPELTDEQLTAAF
                     TELGLSDWLDGLPAGLATGVGERGEALSVGERQLVALARAYVADPDLLVLDEATSAVDP
                     ATEVRLQRTLDAVTRGRTTLAIAHRLSTAQSADEVIVVDRGRIVQRGPHDELVADPDSV
                     YGLLYASWLEQTR"
     gene            complement(7217..9085)
                     /locus_tag="VAB18032_RS21625"
                     /old_locus_tag="VAB18032_26636"
     CDS             complement(7217..9085)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 392; E-value:
                     7.7e-119)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215714.1"
                     /locus_tag="VAB18032_RS21625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26636"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_050814640.1"
                     /transl_table=11
                     /translation="MASGTSRDVLGRGLGVLGRAIREQPRIFAVAVSGSVLFGAMVVAS
                     AFVVGRVVGDVVVPAIERGSVGVSALAIAATALFGLSVLRVVGIFGRRLGAGYMQYRLQ
                     ADYRRRVTRRYLDLPLSWHHRNATGTLLSNANSDVEAAWQPIAPLPFAVGTLVMLVGAV
                     SSLFFTDWALALVGLAVFPALFALNVAYSRRMAPRQARAQRLRAEVSGIAHESFDGALV
                     VKTMGRESQETARFADRTGQLRDALISVGRLRGIFDPMLETLPSLGTLAVLVVGAYRLR
                     QGAIDVAELVSVAFLFTVLAFPVRAIGWVLAELPRSVAGWDRVSRVLDATGEMPYGEQR
                     LAPTAAPASLTFTDVGFAYEPAEAHLPGAQVLGEVSFTVEPGRTVALVGPTGSGKSTIA
                     SLAVRLVDPLAGAVRIDGVDVRQLTADSLAANAALVAQVPFIFDDTIRANVSLDRPGID
                     DEVVWSALRLAEADGFVAALPDGLDTMVGERGTSLSGGQRQRLTLARALAGRPRLLVLD
                     DATSAVDPRVEAAILAGLRSSATGGPGASILVVAYRRATIALADEVIYLEQGRVLARGT
                     HSTLLATVPGYADLVTAYEQAEVDPESTAQDYDEVAPLPSGLEVDR"
     gene            9246..9875
                     /locus_tag="VAB18032_RS21630"
                     /old_locus_tag="VAB18032_26641"
     CDS             9246..9875
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014688766.1"
                     /locus_tag="VAB18032_RS21630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26641"
                     /product="TIGR03085 family metal-binding protein"
                     /protein_id="WP_043721518.1"
                     /transl_table=11
                     /translation="MPRYARSERQALTDLMSGLGPDAPTINEGWTVRDLAAHLVVRERR
                     PDAAAGLVLAPLRDRGERIRRQVAAGDWAQLLDQVRHPPVWSPMSNPLTDELANMMEFF
                     IHHEDVRRAQPQWQPRQLPAELDQALWRRSSTLARMALRRFPAQLTVVAPGHGEVATGR
                     GGEPLRLVGAPGELILFLSGRQRVAQVEIDGAPGLADRLRDAKLGF"
     gene            10001..10933
                     /locus_tag="VAB18032_RS21635"
                     /old_locus_tag="VAB18032_26646"
     CDS             10001..10933
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 235.3; E-value: 1.9e-71)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287567.1"
                     /locus_tag="VAB18032_RS21635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26646"
                     /product="terpene synthase"
                     /protein_id="WP_013735055.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 2.9e-21,
                     bitscore: 74.6, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLALSVLHEPPFTTTQHGDTEVVARESAAWAQELGLISNGQRL
                     HRADAAGLASRACPQAPRDRLRLLSDLITWLFVMDDACDEDGLGNDPTRLSPTAAALLD
                     VLDLHGGPGTVPAAGPLGLALADLCRRVRAYGRPAVMLRFTAAMREYLLALLWEAANRE
                     HDRVPPVHEYVQMRRHTGGVFPSLALTDLALDGLPPAERRADPQWAALELIAANLICWC
                     NDVFSYRKEHRTGPDAHNLVTVLSRETGDERAAMRAAAARFNHELGTYLSTESNLLAQH
                     GDAVRPALTTRRNWIRATYDWSLAAERYA"
     misc_feature    10010..10012
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11074..12897
                     /locus_tag="VAB18032_RS21640"
                     /old_locus_tag="VAB18032_26651"
     CDS             11074..12897
                     /NRPS_PKS="Domain: AMP-binding (14-470). E-value: 6.3e-91.
                     Score: 296.8. Matches aSDomain:
                     nrpspksdomains_VAB18032_RS21640_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     302.3; E-value: 8.9e-92)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475807.1"
                     /locus_tag="VAB18032_RS21640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26651"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_013735056.1"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-89, bitscore:
                     297.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALDVPYRSIPDMFLKRVAATPDRHAFGRPGPDNAPVWLTWSQVA
                     ERAKAVAAGLHGLGVGQEDPVAILANTRLDWIIADFGIMCAGGATTTVYPTTEPDDATY
                     IISDSGSKVLFAEDPGQAAKIAGAQLPALTHVVLIDGEPDPSAAIPQLTLAQLEQQGAE
                     RLADDPELVERLVAKIGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQEAVGLLRD
                     DDLQYLWLPLSHSFGKTLLCGATHVGLPTYVDGRVDKLVELLSVVRPTLMCGAPRVFEK
                     VYNKSVTTAQDAGGAKAKIFAWAVGVGKEKVALEQAGKPLPGGLKFKYALAEKLVFSKL
                     QARLGGRIRVLVSGAAPLSPEIATFFAAANLPISEGYGLTESSAGNFVNPPDGLRIGTV
                     GKAMGDLECRIDSDGEILIKGRPVMRGYHNLPEETAAAFTEDGFFRTGDIGDLDADGYL
                     RITDRKKDLVKTSGGKYVAPSYIEGMFKATCPYTSQAVVIGQARNYCTMLVTLDPDAIA
                     GWAAGTPLEGRPYAEIVASPEAKAMVEEYVAQLNSKLNRWETIKRVTILPRDLTIEDGE
                     ITPSLKIKRRGVESNFSTEIDKMYTGTVVEL"
     aSDomain        11116..12483
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VAB18032_RS21640_AMP-binding.1"
                     /evalue="6.30E-91"
                     /label="VAB18032_RS21640_AMP-binding.1"
                     /locus_tag="VAB18032_RS21640"
                     /protein_end="470"
                     /protein_start="14"
                     /score="296.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LKRVAATPDRHAFGRPGPDNAPVWLTWSQVAERAKAVAAGLHGLG
                     VGQEDPVAILANTRLDWIIADFGIMCAGGATTTVYPTTEPDDATYIISDSGSKVLFAED
                     PGQAAKIAGAQLPALTHVVLIDGEPDPSAAIPQLTLAQLEQQGAERLADDPELVERLVA
                     KIGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQEAVGLLRDDDLQYLWLPLSHSF
                     GKTLLCGATHVGLPTYVDGRVDKLVELLSVVRPTLMCGAPRVFEKVYNKSVTTAQDAGG
                     AKAKIFAWAVGVGKEKVALEQAGKPLPGGLKFKYALAEKLVFSKLQARLGGRIRVLVSG
                     AAPLSPEIATFFAAANLPISEGYGLTESSAGNFVNPPDGLRIGTVGKAMGDLECRIDSD
                     GEILIKGRPVMRGYHNLPEETAAAFTEDGFFRTGDIGDLDADGYLRITDRKKDLVKT"
     CDS_motif       11626..11685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VAB18032_RS21640_0001"
                     /evalue="2.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="VAB18032_RS21640"
                     /protein_end="204"
                     /protein_start="184"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATLIYTSGTTGRPKGVELLH"
     CDS_motif       12313..12387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VAB18032_RS21640_0002"
                     /evalue="5.20E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="VAB18032_RS21640"
                     /protein_end="438"
                     /protein_start="413"
                     /score="28.4"
                     /tool="antismash"
                     /translation="GEILIKGRPVMRGYHNLPEETAAAF"
     gene            complement(12973..14097)
                     /locus_tag="VAB18032_RS21645"
     CDS             complement(12973..14097)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018479.2"
                     /locus_tag="VAB18032_RS21645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="low temperature requirement protein A"
                     /protein_id="WP_232510842.1"
                     /transl_table=11
                     /translation="MLALLWWAWTGFAVVGNVVRTDQGVLPFLTFATTAAAFVFTLAMS
                     QAFRDRPGDLSGPLVFAVCYFAVRASQVAILGWLAHGDPELRRRFLLVAGRGLLVGVLV
                     LAAALLPQSLTTETGEISLRLTLWIVALAVEYGAGLLLRGSGWTVLSAGHWAERHALIV
                     LVALGETIIALGLGGGVDTESPLTWRVVVAALLAVAVVSSWWWAYFDTMALAMEQVLHR
                     TRDRLARAVLARDAYTYLHLLLVAGPILFALGLKGLIGGRGTPGGELPVFDLAVLFGGA
                     ATYLVGLVALGWRVLRLVRWPSLAAVAGLALLAPVAARLPAVTALALLTGIMLVATVVQ
                     TRVDAPLRREVRETAWAEQVAAEAEQSEWRRRHL"
     gene            complement(14107..14271)
                     /locus_tag="VAB18032_RS32980"
     CDS             complement(14107..14271)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="VAB18032_RS32980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="low temperature requirement protein A"
                     /protein_id="WP_232510843.1"
                     /transl_table=11
                     /translation="MGDVGRVHWSRGVWPNAPGSRVTRLELFYDLVFVFAFIRVTTLTA
                     ETPTARGLV"
     gene            complement(14328..15785)
                     /locus_tag="VAB18032_RS21650"
                     /old_locus_tag="VAB18032_26666"
     CDS             complement(14328..15785)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (142-463). E-value:
                     5.3e-27. Score: 86.7. Matches aSDomain:
                     nrpspksdomains_VAB18032_RS21650_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 289.2; E-value:
                     8.2e-88)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014395.1"
                     /locus_tag="VAB18032_RS21650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26666"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_043721521.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.7e-25, bitscore:
                     86.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQVRGAQLARLLGQWHALPGRRRSPDYAALAGAVRGLLADGRL
                     PLGVRLPAERDLAEALQISRTTVTAAYRELRDSGHLASRRGAGSWTMLPGTHRVASNGL
                     WIPLDDREMLDLGVAALAAPPELLPAARAAAEDLPRYLGGAGYHPIGIIELREAVAQAY
                     VDRGLPTSPDQIMVTNGTQHALDLVLRLALAPGGSVLVESPSYPNALAALAARRARITT
                     HGLSAELDGWDADLMLGSLRQVRPRVAYLIPDFQNPTGHLMPAELRERLVATAHAVGTD
                     LVIDESFVDLSLDDAVLPPPTASFDRHSRVVSIGGMSKPFWGGLRIGWIRASAPQVQRL
                     AAARVGVDMASPVLDQLVAVHLMAAAPAIVAARRAQLTEQRDALLGALAARLPEWRVSV
                     PRGGVTLWAELDGPISSALARAAEEVGVRLAPGPRFGLDGTLERFLRLPFTLPSADLVE
                     AVGRIAAVRYDLDRGGAPRWREPSVIA"
     aSDomain        complement(14397..15359)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VAB18032_RS21650_Aminotran_1_2.1
                     "
                     /evalue="5.30E-27"
                     /label="VAB18032_RS21650_Aminotran_1_2.1"
                     /locus_tag="VAB18032_RS21650"
                     /protein_end="463"
                     /protein_start="142"
                     /score="86.7"
                     /tool="antismash"
                     /translation="GGAGYHPIGIIELREAVAQAYVDRGLPTSPDQIMVTNGTQHALDL
                     VLRLALAPGGSVLVESPSYPNALAALAARRARITTHGLSAELDGWDADLMLGSLRQVRP
                     RVAYLIPDFQNPTGHLMPAELRERLVATAHAVGTDLVIDESFVDLSLDDAVLPPPTASF
                     DRHSRVVSIGGMSKPFWGGLRIGWIRASAPQVQRLAAARVGVDMASPVLDQLVAVHLMA
                     AAPAIVAARRAQLTEQRDALLGALAARLPEWRVSVPRGGVTLWAELDGPISSALARAAE
                     EVGVRLAPGPRFGLDGTLERFLRLPFTLPSADLVEAVGRI"
     gene            15844..16500
                     /locus_tag="VAB18032_RS21655"
                     /old_locus_tag="VAB18032_26671"
     CDS             15844..16500
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018832747.1"
                     /locus_tag="VAB18032_RS21655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26671"
                     /product="hypothetical protein"
                     /protein_id="WP_086011295.1"
                     /transl_table=11
                     /translation="MMLIGNLRHRPVRRLVQLFGGLLLYGASMALMVRSELGLNPWDVF
                     HQGVSRLTGLSMGTVVIAVGLLVLLAWIPLRQRPGIGTLANAVVVGLAVDLTLALLPPV
                     EPLAAQIALLTAGIVGNGMATALYLGARLGPGPRDGLMTGFTARRPGRSLRLVRTVMEV
                     VVLAVGALLGGKLGVGTIAYALAIGPLAQFFLPRFDVPEPHPGTTTPRIETAPTP"
     gene            16644..17105
                     /locus_tag="VAB18032_RS21660"
                     /old_locus_tag="VAB18032_26676"
     CDS             16644..17105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072134.1"
                     /locus_tag="VAB18032_RS21660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26676"
                     /product="hypothetical protein"
                     /protein_id="WP_013735059.1"
                     /transl_table=11
                     /translation="MGENAWRRTDAWIFVSLVIASGAGRHRRSPTTRRPEGVRLADVLS
                     TADHLDQSIPERHDIEEAIRRLLGAGLVDVADGWFRITPAGERLWRSRPTAGLATTVDT
                     VQSVLDRRHAPGTAEWHLDEAEHAAAVQEYLVRTIPMPRQSPEGHSGRS"
     gene            complement(17118..17885)
                     /gene="hisF"
                     /locus_tag="VAB18032_RS21665"
                     /old_locus_tag="VAB18032_26681"
     CDS             complement(17118..17885)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019900882.1"
                     /locus_tag="VAB18032_RS21665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26681"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="WP_013735060.1"
                     /transl_table=11
                     /translation="MTVAVRVIPCLDVDAGRVVKGVNFLDLRDAGDPVELAAAYDRAGA
                     DELTFLDVTASSSDRGTMLDVVRRTAESVFIPLTVGGGVRAVADVDTLLRAGADKVGVN
                     TAAIARPELIAEIADRFGRQVLVLSLDVRRAPAGTTPSGFEVTTHGGRRGTGLDAVQWA
                     QRVAELGAGEILLNSMDADGTKAGFDLELIGAVRRVVDVPVVASGGAGEVAHFPPAIGA
                     GADAVLAASVFHFGELTVGEVKDALRTAGHPVR"
     gene            complement(17896..18621)
                     /gene="priA"
                     /locus_tag="VAB18032_RS21670"
                     /old_locus_tag="VAB18032_26686"
     CDS             complement(17896..18621)
                     /EC_number="5.3.1.16"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0003949 - 1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="priA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018813684.1"
                     /locus_tag="VAB18032_RS21670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26686"
                     /product="bifunctional 1-(5-phosphoribosyl)-5-((5-
                     phosphoribosylamino)methylideneamino)imidazole-4-
                     carboxamide isomerase/phosphoribosylanthranilate isomerase
                     PriA"
                     /protein_id="WP_013735061.1"
                     /transl_table=11
                     /translation="MSLTLLPAVDVADGQAVRLVQGAAGSETTYGDPLEAALAWQRDGA
                     EWIHLVDLDAAFGRGSNAALLAEVVRRLDVQVELSGGIRDDASLRAALATGATRVNIGT
                     AALEDPQWCDRICGEYGDRVAIGLDVRGRTLAARGWTRDGGDLYEVLERLDKAGAARYV
                     VTDITKDGTMRGPNLDLLREVCARTDAPVIASGGVSTLDDLRALATLEPIGVEGVIAGK
                     ALYAGAFTVAEALQALAEQ"
     gene            complement(18641..18964)
                     /locus_tag="VAB18032_RS21675"
                     /old_locus_tag="VAB18032_26691"
     CDS             complement(18641..18964)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014402.1"
                     /locus_tag="VAB18032_RS21675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26691"
                     /product="hypothetical protein"
                     /protein_id="WP_043725305.1"
                     /transl_table=11
                     /translation="MSKERARRRAVREAEAARRRVARERALARRARRRALIRRMVPTVR
                     RGRTGRLLRYSRRERATIVALTLAAIALIWVLVPDLALRVVLIVLLLLVLPVIVVVALD
                     RRS"
     gene            complement(19016..19669)
                     /gene="hisH"
                     /locus_tag="VAB18032_RS21680"
                     /old_locus_tag="VAB18032_26696"
     CDS             complement(19016..19669)
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183512.1"
                     /locus_tag="VAB18032_RS21680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26696"
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="WP_013735063.1"
                     /transl_table=11
                     /translation="MTDRDTPRPRVVVLDYGSGNLRSAERALAAAGADVTVTDDLVAAA
                     DADGLVVPGVGAFAACMAGIEALGAGPVIAGRVAAGRPVLGICVGMQILFESGDEHGVI
                     TKGLGLLPGNVTRLPAARLPHMGWNTVAPPVGSVLFAGLPADSRFYFVHSYAVCDPTAL
                     LAAGARVTTAHHDADFVAAVERGPLSAAQFHPEKSADTGATLLRNWLATVPTDG"
     gene            complement(19666..19839)
                     /locus_tag="VAB18032_RS32385"
                     /old_locus_tag="VAB18032_26701"
     CDS             complement(19666..19839)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020610622.1"
                     /locus_tag="VAB18032_RS32385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26701"
                     /product="hypothetical protein"
                     /protein_id="WP_013735064.1"
                     /transl_table=11
                     /translation="MSSILPTLLLIFAGVLVGGTWSLHRQGAPRGAVVVTALLAVLATV
                     AGVLWLLPGEGS"
     gene            complement(19874..20485)
                     /gene="hisB"
                     /locus_tag="VAB18032_RS21685"
                     /old_locus_tag="VAB18032_26706"
     CDS             complement(19874..20485)
                     /EC_number="4.2.1.19"
                     /GO_function="GO:0004424 - imidazoleglycerol-phosphate
                     dehydratase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019531759.1"
                     /locus_tag="VAB18032_RS21685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_26706"
                     /product="imidazoleglycerol-phosphate dehydratase HisB"
                     /protein_id="WP_013735065.1"
                     /transl_table=11
                     /translation="MSRTARVERITKETKVLVEIDLDGAGAAEISTGVGFYDHMLHQIA
                     RHGGFDLTVQTVGDLEIDAHHTMEDTALALGAAFDQALGDKAGIRRYGSATVPMDEVLV
                     RAAVDLSGRPYVVHDEPLLTPYIGPVYPTSMTRHIWESFGQAARITLHVDVLRAARPGG
                     HPDAHHVVEAQFKAVSRALREATAIDPRSAGVIPSTKGAL"
ORIGIN
        1 ttcgtcgagg gcggacgacg tggtggagtc caccacccag gtgcgggtca ccgcccagag
       61 cgccagcccc gcgcccgcca ggcagagcag cacggcgtac gccaactcac gtcgggcggt
      121 catcgggctg ctctcagggt ttcggcggcg gcgatggctg ccagtaccgc ggcggccttg
      181 ttgcgggtct cctggtcctc ggcggccggg tcggagtcgg ccaccacgcc ggcaccggcc
      241 tggacgtagg cgcggccggc gcgcatcagg gcggtccgga tcgcgatggc catgtcgagg
      301 tcgccgccga agccgaagta gccgaccgtg ccgccgtaga ggccccggcg taccggttcg
      361 agttcctcga tgatctccat ggcacgcacc ttgggggcgc cggagagggt gcccgccggg
      421 aacgtcgcgg ccagcgcgtc gaaggccgta cggtcctcgc gcagggtgcc gaccacggtc
      481 gagacgatgt gcatgacgtg gctgtaccgc tcgatggtgg cgaactccgg cacctcgacg
      541 gtgccgggcc ggcagacccg acccaggtcg ttgcggccca ggtcgacgag catgacgtgc
      601 tcggcccgtt ccttcgggtc ggcgagcagt tcggcggcga ggcgggcgtc ggcctccggg
      661 gtcgcgccgc gcgggcgggt gccggcgatc gggtgcagca gggcgcgccg ctcgccgctc
      721 tcctcgattg tcaccttcag gtgcgcctcg ggcgacgaac cgacgatgtc gaagtcgtcg
      781 aagcgcagaa ggtacatgta ggggctgggg ttggtggtac gcagcacccg gtagacgtcc
      841 agcgggtcgg cggcggtgtc ccgttcgaag cgttgggcca gcacgatctg gaagcactcg
      901 ccggcccgga tcgcctcctt ggccgcctcg accgccttgg ggtagccgcc gtcgggggta
      961 cggctgcgca cctcgccgac gggtgggcgg tgcaccgtgg agaccatcgg cgggatgggc
     1021 cgcgacagcg cggtggtcat cgcgtccagc cgacccaccg cgtggtggta cgcggcggcg
     1081 accagcgctt cgcggcccgg ctcgtcctgc gggggcagga tcgcgttggc gaccaggatc
     1141 gccgagccgt cgaagtggtc gagcaccacc aggtcggtgg cgagcatcat gcccagttcg
     1201 ggtacggcca ggtcgtcctc ggtgagcgcg ggcagccgct cgaagcgccg gatcaggtcg
     1261 taaccgaggt agccgaccat gcccccggtc agcggcggca tcccgccctg cgggtcgccg
     1321 ggcgggcccg ccagcgcggc caccgtggcc cgcagcacct cgaccgggtc gccggtggtc
     1381 ggcagtccgg ccgggggcgt gccgagccag gccgccgcgc cgtcccgttc gacaagggtg
     1441 gcgctgctgc gtacgccgac gaaggagtac cgggcccagg ccagccccgc cgagccgacg
     1501 ccctgttcgg cggattccag caggaaggtg ccggggccac cggcgagctt gcggtagacc
     1561 ccgaccggcg tctccgcgtc ggcgagcagc cggcgggtca ccggcaccac ccgccagcgg
     1621 gccgccagtt cggtgaaggt ggtctcgtcg gggctcaccc gaccgtcggt catgaggtca
     1681 cctcgccggt gaccggaagc tcggtatgga agcaggtgcg ctgcccggtg tggcaggcgg
     1741 cacccacctg gtcgacgctg accagcacgg catcgccgtc acagtccagc gcgaccgagc
     1801 ggacgtactg gtggtggccc gacgtggcgc ccttgaccca gtactcccgg cgactgcgcg
     1861 accagtaggt ggcccggccg gtggtcaggg tgcggtgcag ggcctcgtcg tccatccagg
     1921 cgaccatcag cacctcaccg ctgtcgtgct gacggaccac ggcggccacc aggccgtcgg
     1981 gggtccggcg cagccgggcg gcgatcgccg ggtcgagccg ggacggccgg tccgggccgc
     2041 cgggcggggg cgaccttcgc ggtgggcgcc ggtcaccggc gcgtcaggta cgggcacagt
     2101 tagccattgt tccgcacgcg gagcgggtac cccagcggcc tcccgaccgt cggacggcac
     2161 cgccccggtc gactcgcgac ctggcgacgg cacggcggcg gactcctggc cggtgtgctg
     2221 gggcgggacc acggggtggc ccagctgggc cacgtagcgg tccaaccggc cgtcgagcag
     2281 ggcggcggcg aggtccgcgc cgccgacctc cgccacctcg gcggcgtacg ggcggatcaa
     2341 cgggagggtg ccggccacca ggcgggccgc ggcggcccac agttggcggg tcgagccggg
     2401 ccgcaacccg agacagcgca gcatggcctc gcggtagccg gcgggtgcca ccggcaggtc
     2461 gagcgcggcg gtgaacgccg accggcggga caccacccgt acggagggat tggccagtcg
     2521 cagcaccgag gggcagagcc gcgccaggtc ggcggcggcc agccggaccc cgagccggtc
     2581 gtcggcgtcc cgggccgagg ccaccttgcc gaggctggcg atcatttcct ccagccgtgg
     2641 ctcgtcggcc ggctggcaga gcaccggcag gtcgatccgg gcccgccagc gcggatccgc
     2701 ccacagcagc cgggcgggag ccgtcacggg caggccgaac gcccagtcgg ccggttcgcc
     2761 cagtcgggtc acccacgacc ggatgtcccg agccgcgacc gagacgtggg tcagccggcc
     2821 ggaatgctcc gcgatgtagg cccggcgggc cgcgtacggc gcaccaccgc cgaccagaac
     2881 gtcgacgtcg acgtcgctgt gggcggtggc ggcccgacgg gcgtggctgc cgcggagcag
     2941 aatgcccacc acgggtcggt cggcgctcgc ccgcagccgt gcggtccagt cgtcgaagaa
     3001 tcggctgtcc gatgacggag cgtgatccac tgcgccatcc tgccgcaggt ccgatctagg
     3061 tgcaatgccc gatgacggac tctgtgtccg ttaaatcatt agttgcccgt ggtatcagcc
     3121 cgcgattcac ttccggcctt tcccggtcga cccaattcaa ctagcgttga tttcaacagt
     3181 tgatgagttt gttgggaggt ggacgatggt cgacgcgatc gccgtccggg gcctggtcgt
     3241 ggaccggggc ggacggcgag ttctggacgg catcgacgcc gtcgttcccg gcggctcggt
     3301 caccgggctg ctcgggccga gcggaagcgg caagaccacc ctgatgcggg cgatcgtcgg
     3361 agtgcaggtg atcacggccg gcgcggtgac ggtgctgggt cagccggccg gctcggcggg
     3421 tctgcggcac cgggtcggct acctgaccca ggcgccgagc gtctacgccg acctcacggt
     3481 ccgggagaac gcccgctact tcgccaccct ccacggccgg ggcgcggacg aggcggaccg
     3541 ggctgtggcc gacgtgggtc tggccgccgc ggcacgacag ttggtgggca acctctccgg
     3601 tgggcagcgc agccgggcat cactggcctg cgtacttgtc ggtgacccgg agttgatcgt
     3661 gctcgacgaa ccgactgtcg gtcaggatcc ggtgctgcgc gccgacctct gggcccgctt
     3721 ccacgaactg gccgcggccg ggacgacgct gctggtgtcg agtcacgtga tggacgaggc
     3781 ggcccgctgc gaccggctgc tgctgatccg cgccggacgg ctggtcgccg acgacacgcc
     3841 ggacgccgtc cggtccgccg ccggggtgga cgacctcgac gaggcgttcc tgcggctgat
     3901 cagggcggcc gagacgacgc aggccgggga ggcgtgatga acagccggat tctcgtcgcc
     3961 accgtcgggc gcatcctgcg tcaactgcgc cacgaccggc gtacggtggc cctgctcgtg
     4021 gtggtgccca ccgtgctgct cacgcttgtc tactacatgt acgccgacca gcccagcgtg
     4081 ccgggaacgt cgtccgcctt cgaccggatc gcgctggtca tgctcggctt cttcccgttc
     4141 atcatcatgt tcctggtgac cagcatcgcc atgctccgcg agcggaccag cggcacgctg
     4201 gaacgactgc tgaccacgcc gctggccaag gccgacctgc tcttcgggta cggcatcgcc
     4261 ttcgggctgg ccggcgcggt acaggccacc atcgcctcgg ccgtggcgta ctgggtcttc
     4321 gacctgcaca ccgccggcag cagcgggttg gtgatcatga tcgccgcgtt gaacgcggtg
     4381 ctggccgtcg cgctcggcct gctgtgcagc gccttcgccc gcaccgaatt ccaggccgta
     4441 cagttcatgc cggtcgtggt cgcgccgcag ctgctgctct gcgggctgtt cgtaccgagg
     4501 gagcagatgg ccggctggtt gcaggcggta agcgacgcgc tgcccctgac gtacgccgtc
     4561 gaggctctgc aggaggtggg cgcgcacgcc gagccgaccg ccacgatgtg gcgcgacgtg
     4621 gccgtggtcg ccgccgtggc ggtgctggcg ctgctgctcg ccgcggccac cctgcgacga
     4681 cgcagcagct gacacccgcg tccgggccgc cggctgacac gtcggcggcc cggacgcggc
     4741 gtggcaccga gcggaaggag gacgatggca cggcggaccg gtcgacgccc cggcaacccg
     4801 gcgacccgcg aggcgatcct cgacgcggcc cgggccacct tcgggcagcg ggggtacgac
     4861 ggcagcacga tccgggccat cgccgccgcc gccggagtgg acccggccct ggtgcaccac
     4921 tacttcggca gcaaggacca gctcttcctg gccgccatgc aggcgccgtt cgacccccgg
     4981 gaggtgctgc ccgcggtgct cgccggcgac cgcgcgggcc tcggcgaacg gatcgtgcgg
     5041 accttcctct cggtgtggga ctcccccgcc ggcaccgccg ggatcgccat gctgcgctcc
     5101 gcggtcagca acgaatggac cgcccggctg ctgcgcgagt tcgtcaccat ccacgtgctg
     5161 cgcccgatcc tcgaccacgt cgacgtcgac ccggcggagg tgccgctacg cgggtcactg
     5221 ctggccagcc aactggtcgg gctggcggtg atgcggcacg tgatccggct ggagccgatc
     5281 gccaccgccg atcccgaggt cctggtcgcc gcgatcgccc ccaccatcgg gcgctacctc
     5341 accgccccgc tctgatcagc gggtctgttc cagccaggag gcgtagagca ggccgtagac
     5401 cgaatccggg tcggcgacca actcgtcgtg cggaccgcgc tgcacgatcc ggccccggtc
     5461 caccacgatc acctcgtcgg cgctctgcgc cgtggagagc cggtgcgcga tggccagggt
     5521 ggtccggccc cgggtcaccg cgtccagggt ccgttgcagc cggacctccg tggccgggtc
     5581 gacggcgctt gtcgcctcgt ccagcaccag cagatccgga tcggcgacgt acgcccgggc
     5641 caacgcgacc aactgccgct cccccacgct caacgcctca ccacgctcgc cgaccccggt
     5701 ggccaaaccg gccggcagac cgtccagcca gtcactcagc cccaactcgg tgaaggcggc
     5761 ggtgagctgc tcgtcggtca actcggggcg accgaagcgg acgttgtcgg cgacggtggc
     5821 gtcgaacagg aagccgtcct gcggcaccat caccacccgg gaacgcagcg attcgaaccg
     5881 gacgtcggtc agtggcaccc cggagagcag cacgtcgccc tgggtcgggt ccatcagtcg
     5941 ggtgagcagc ttggcgaagg tggtcttgcc gctgccggtc tcgccgacca ccgccacccg
     6001 gctcttcgcc gggatctcca ggctgacgtc gtgcagcacc gtcgggccgt tcgggtaggc
     6061 gaaactcacc ccggcgaacc ggatgtccag cgggccgggc ggcaactccc gcccctgctc
     6121 gcccgggtcg gccacgtccg gggacacgtc cagcacatcc agcacccgac gccagccggc
     6181 gatcgcgttc tgcgcctcgt tgagcacctc cgtggcgatc tgcacgggct ggatgaacaa
     6241 cgtcacgagg aacaggaacg cggtgacctc accgatgctc agcgtctggt cggcgccgag
     6301 aagcacaccg acgaccacca ccccggccag cgccaccccg gcggccagct cgccgaccga
     6361 actgcccaga atgctgatcc ggatcgcctt ctgctgggcc tgccgttgac tgtcgatcgc
     6421 ctggtccagc cgccgggcgg tgcgcccggc gatgccgtac gcccggatca ccggcgcacc
     6481 caccacgctc tcaccgaccg cgccgagcaa cgcgccggtc cgctgccgga ccaccccgta
     6541 cgcggcggcc agtcggcgct gcagcagccg gatcaccagg accgccggta cgaaggcggc
     6601 gaagaccacc agggtcaact gccaggagta cgccagcatc accactgtgg tgaccgccaa
     6661 ctgccccagg ttgaccagca ggatcacgcc accccactgg aggaactggg tgatctggtc
     6721 gacgtcgctg gtcacccggg acaccagcga accccgccgc tcggactgct ggtgcaacat
     6781 cgacaggtcg tgcacgtgcc ggaaggcccg cacccgtacg ccggccagcg cggtctcgct
     6841 gacggtgaac agtcgtcgca tcatcaggta gccgcaggcg gtggtcacca ccagcacggc
     6901 agcggtcacc gccaccacga cgaacagggc gttcaggtcg agcccaccga cgatgccccg
     6961 gtcgatgccc tgctgcacgg ccaccggtac ggccacccgg ccgagcatgt agaccaacgc
     7021 caggccgagc gtgccggcca ggcccacccg caactccggg gacagggcca ggccacggcg
     7081 cagcgtcgcc caggtcgact cgacccgttc cgacgccgcg ttcaccggtc caccttcgtt
     7141 cccgaccgcg ggactgcgct gcgccgcgtt cctcgcgctc accggaccca cccttcgttc
     7201 cctaccttcc tcgcggtcac cggtccacct ccaggccgga gggcaggggg gccacctcgt
     7261 cgtagtcctg cgctgtgctc tcggggtcga cctcggcctg ttcgtaggcg gtgaccaggt
     7321 cggcgtagcc cggcacggtg gccagcaacg tcgaatgggt gccgcgggcg agcacccggc
     7381 cctgctccag gtagatgacc tcgtcggcga gcgcgatggt ggcccggcgg tacgccacca
     7441 ccaggatcga cgcgccggga ccaccggtcg ccgacgagcg cagcccggcc aggatggcgg
     7501 cctccacccg agggtcgacc gcgcttgtcg cgtcgtcgag caccagcagc cggggtcgcc
     7561 cggccagcgc ccgggccagg gtgaggcgct gccgttggcc gccggagagc gaggtgcccc
     7621 gctcgccgac catggtgtcc agtccgtcgg gcagggcggc gacgaagccg tcggcctcgg
     7681 ccaaccgcaa cgcgctccag accacctcgt cgtcgatgcc cggccggtcc agcgagacgt
     7741 tcgcccggat cgtgtcgtcg aagatgaacg gcacctgcgc gaccagggcg gcgttggcgg
     7801 cgagcgaatc cgcggtcaac tgccgcacgt ccaccccgtc gatgcggacc gcgccggcca
     7861 gcgggtccac cagccgcacg gccagcgaag cgattgtcga tttgccggag ccggtcggcc
     7921 cgaccagggc gacggtcctg ccgggctcga cggtgaagga gacctcgccg agcacctgcg
     7981 cgccgggcag gtgcgcttcg gcgggctcgt aggcgaagcc gacgtcggtg aaggtgagcg
     8041 aggccggcgc ggcggtgggg gcgagccgct gctcgccgta cggcatctcg ccggtggcgt
     8101 cgagcacccg gctgacccgg tcccagccgg cgacgctgcg cggcagttcg gccagcaccc
     8161 agccgatcgc ccgcaccgga aacgccagca cggtgaagag gaaggccacg ctgaccagct
     8221 ccgccacgtc gatggccccc tggcgcaggc ggtacgcacc gaccaccagc accgccaggg
     8281 tgccgaggct gggcagggtc tccagcatcg gatcgaagat gccgcgcagc cggcccacgg
     8341 agatcaacgc gtcgcgcagc tgtccggtcc ggtcggcgaa ccgggcggtc tcctgactct
     8401 cccggcccat cgtcttgacc accagcgcgc cgtcgaagct ctcgtgggcg atcccgctga
     8461 cctcggcccg cagccgctgg gcacgggcct gccgcggtgc catccgccgg gagtaggcga
     8521 cgttgagcgc gaacagtgcc gggaacaccg ccagcccgac cagggccagc gcccagtcgg
     8581 tgaagaagag cgacgacacc gcgcccacca gcatcaccag cgtgccgacc gcgaagggca
     8641 gcggggcgat cggttgccag gccgcctcca cgtcggagtt cgcgttggac agcagggtgc
     8701 cggtggcgtt gcggtggtgc caggacaacg gcaggtcgag gtagcggcgg gtgacccgac
     8761 gccggtaatc ggcctggagg cggtactgca tgtatcccgc gccgagtcgc cgaccgaaga
     8821 tgccgaccac ccgcagcacg ctgagcccga acagcgcggt ggccgcgatg gccagggcgc
     8881 tcaccccgac cgagccgcgc tcgatcgccg ggaccaccac gtcgccgacc acccgaccga
     8941 ccacgaatgc gctggccacc accatcgcgc cgaacagcac gctgccgctg accgcgaccg
     9001 cgaagatcct cggctgttcg cggatggccc gtcccaggac gcccagcccg cgaccgagca
     9061 cgtcccgact tgtcccgctc gccactgtct cccccgccgt aagccgccag tatcctctct
     9121 catccttacc gttgcccgct cgtcccgccg accccgggtg atatgtccga cgtcacctcc
     9181 ggccggagca accggcgcac cggcgaaccc ggcaggaccg gtcagttgca cctaccatcg
     9241 cagtcatgcc gcggtacgcc cgatccgaac gccaagcgct caccgatctg atgtcagggt
     9301 tgggaccgga cgcccccacc atcaacgagg gttggacggt tcgcgacctc gccgcacacc
     9361 tcgtggtacg cgagcgtcga ccggacgccg ccgccggcct cgtgctcgcc ccgctgcgcg
     9421 atcgcggcga gcggatccgc cggcaggtcg cggcgggcga ctgggcgcaa ctgctcgacc
     9481 aggtacgcca ccctccggtg tggagcccga tgagcaaccc gttgaccgac gagttggcca
     9541 acatgatgga gttcttcatc catcacgagg acgtacgccg ggcccagccg cagtggcagc
     9601 cgcgccagtt gccggccgaa ctggaccagg cactgtggcg gcgcagctcc accctggcgc
     9661 ggatggcgct acgccggttc ccggcccagt tgacagtcgt cgcgccgggg cacggcgagg
     9721 tggccaccgg ccggggcggt gaaccgctgc ggctggtggg cgcgccgggc gagctgatcc
     9781 tgttcctgtc cggtcggcag cgggtggcgc aagtggagat cgacggcgcc cctggcctgg
     9841 cggatcggct acgcgacgcc aagctgggct tttagccaaa tgtgcagaag cagccagtga
     9901 acagaatcga aacgttatac agccaacacc ctgcgttgat cgaggctccc gtactctggc
     9961 cgcgccgctc cgctccgggg gcggcggaac agggaactcc atgcgaacct tagcgctctc
    10021 ggtactgcac gagcccccct tcaccacgac ccagcacggc gacaccgaag tggtggctcg
    10081 ggaaagcgca gcctgggcac aagagctagg tctgatcagt aacggacagc gactgcatcg
    10141 ggccgacgcc gccgggctcg ccagccgggc ctgcccacag gcaccccgtg accgcctgcg
    10201 cctgctctcc gacctgatca cctggctgtt cgtgatggac gacgcctgcg acgaggacgg
    10261 tctgggcaat gatccgacgc gcctctcgcc caccgcggcg gccctgctgg acgtgctgga
    10321 cctgcacggt gggccgggca ccgtaccggc cgccggcccg ctggggctgg cgttggccga
    10381 cctgtgccgg cgggtgcgcg cctacggacg gccggccgta atgctgcggt tcaccgccgc
    10441 catgcgggaa tacctgctcg cgctgctgtg ggaggcggcc aaccgggagc acgaccgggt
    10501 gcctccggtg cacgagtacg tgcagatgcg ccggcacacc ggcggcgtgt tccccagcct
    10561 cgccctgacc gacctggctc tggacggtct gccgccggcc gaacgccggg ccgacccgca
    10621 gtgggccgcc ctggagttga tcgccgccaa cctgatctgc tggtgcaacg acgtcttctc
    10681 gtaccgcaag gagcaccgga ccggcccgga cgcgcacaac ctggtcaccg tgctgagccg
    10741 ggagaccggg gacgagcggg cggcgatgcg ggccgccgcg gctcgcttca accacgaact
    10801 cggcacctat ctgagcaccg agagcaacct gctggcgcag cacggcgacg cggtacgacc
    10861 ggcgttgacg acgcgacgga actggatccg ggccacctac gactggtccc tggcagcgga
    10921 gcggtacgcc tgagacaggc attcggcacg ggaaacgggc ctggtggatg atccggaggt
    10981 ctagccgatg ccccgcacag gcaataccct tcggtaacca acaccggccg tgacgatggt
    11041 cacgcctcca cccccctgaa ggcggctaca gcgatggctc tcgatgtacc gtaccgctcc
    11101 attcctgaca tgttcctcaa gcgcgtggca gccaccccgg atcgtcacgc tttcggtcgc
    11161 cccggtccgg acaacgcccc ggtctggctg acctggtccc aggtcgccga gcgggccaag
    11221 gcggtcgccg ccggtctgca cggtctgggt gtcggccagg aggatccggt ggcgatcctg
    11281 gcgaacacgc gactcgactg gatcatcgcc gatttcggca tcatgtgcgc cggtggcgcg
    11341 acgaccacgg tctacccgac caccgaaccc gacgacgcca cctacatcat ctccgactcc
    11401 ggttcgaagg tgctgttcgc cgaggacccg ggacaggcgg cgaagatcgc cggtgcgcag
    11461 ctgcccgcgc tgacccacgt ggtcctcatc gatggtgagc cggacccgtc ggcggccatc
    11521 ccccagctga ccctcgctca gctcgaacag cagggcgccg agcggctcgc cgacgatccg
    11581 gaactggtcg aacgcctggt cgccaagatc ggtcccgacc acctggccac cctgatctac
    11641 acctccggca ccaccggccg acccaagggc gtcgagctgc tgcacggcgg ctggtgctgg
    11701 gagggtgtcg cgcaggaggc ggtcgggctg ctgcgcgacg acgacctgca gtacctctgg
    11761 ctgccgctgt cgcactcgtt cggcaagacg ttgctctgcg gcgccaccca cgtgggcctg
    11821 ccgacgtacg tcgacggtcg ggtcgacaag cttgtcgagt tgctctcggt ggtccggccg
    11881 acgctgatgt gcggtgcgcc ccgggtcttc gagaaggtct acaacaagtc ggtgaccacc
    11941 gcgcaggacg ccggtggcgc gaaggcgaag atcttcgcct gggcggtcgg ggtcggcaag
    12001 gagaaggtcg ccctggagca ggccggcaag ccgctgcccg gcgggctgaa gttcaagtac
    12061 gcgctggccg agaagctggt cttcagcaag ctccaggccc gcctcggtgg ccggatccgg
    12121 gtcctggtgt cgggggccgc cccgctcagc ccggagatcg ccaccttctt cgccgccgcg
    12181 aacctgccga tctccgaggg ctacgggctc accgagtcca gcgccggcaa cttcgtcaat
    12241 ccgccggacg ggctgcgcat cggcacggtg ggcaaggcga tgggcgacct ggagtgccgc
    12301 atcgactctg acggcgagat cctgatcaag ggtcgaccgg tgatgcgtgg ctaccacaac
    12361 ctgcccgagg agaccgccgc cgccttcacc gaggacggat tcttccgcac cggcgacatc
    12421 ggcgacctcg acgccgacgg ctacctgcgc atcaccgacc ggaagaagga cctggtcaag
    12481 acctccggcg gcaagtacgt cgccccgtcg tacatcgaag gcatgttcaa ggcgacctgc
    12541 ccgtacacct cgcaggccgt cgtcatcggc caggcccgca actactgcac catgcttgtc
    12601 acgctcgacc cggacgccat cgccggctgg gcggcgggca cgccgctgga gggtcggccg
    12661 tacgccgaga tcgtcgcctc gccggaggcg aaggcgatgg tcgaggagta cgtcgcgcaa
    12721 ctgaacagca agctcaaccg ctgggagacc atcaagcggg tcaccattct gccgcgtgac
    12781 ctgaccatcg aggacggcga gatcaccccg tcgttgaaga tcaagcgtcg cggggtggag
    12841 agcaacttct ccaccgagat cgacaagatg tacaccggca ccgtcgtcga gctctgacgg
    12901 cacgcccgcg cgcacctggc cgagccggcc ccgcccgcgg ggccggctcg gcgcgcagcc
    12961 aggtcgggcc gctcacaggt gccgtcgacg ccactcggac tgctcggcct cggcggcgac
    13021 ctgctcggcc cacgccgtct cgcgcacctc gcggcgcagc ggtgcgtcca cccgcgtctg
    13081 caccaccgtc gccaccagca tgatcccggt gagcagcgcc agcgccgtca ccgccggcag
    13141 ccgcgcggcg accggcgcca gcagcgccaa cccggccacc gcggccaggc tcggccaccg
    13201 caccaggcgc aacacccgcc agccgagcgc caccaacccg accaggtagg tcgccgcccc
    13261 gccaaagagc accgccagat cgaagacggg caactcgccg cccggggtgc cccgcccgcc
    13321 gatcaggccc ttgagcccca gggcgaacag gatcgggccg gcgaccagca gcagatgcag
    13381 ataagtgtac gcatctcggg ccagcacggc ccgggccagc cggtcccggg tgcggtgcag
    13441 cacctgctcc atggccaacg ccatggtgtc gaagtacgcc caccaccacg agctgaccac
    13501 cgccacggcg agcagcgccg cgacgaccac ccgccaggtc aacggcgact cggtgtcgac
    13561 tccgccgccc aacccgaggg cgatgatcgt ctcgccgagc gccaccagca cgatcagcgc
    13621 gtgccgttcc gcccagtgac cggccgacag caccgtccag ccgctgcccc gcaacaacaa
    13681 cccggcgccg tactccacgg ccagcgcgac gatccacagc gtcagccgca gactgatctc
    13741 gcccgtctcg gtggtcaacg actgcggcag cagcgcggcg gccagcacca gcaccccgac
    13801 cagcagtcca cgcccggcca cgagcaggaa acggcggcgc aactccggat cgccgtgagc
    13861 cagccacccg aggatggcca cctggctggc ccgcaccgcg aagtagcaga cggcgaagac
    13921 cagcgggccg gacaggtcgc cgggccggtc ccggaacgcc tgcgacatgg cgagggtgaa
    13981 cacgaaggcc gcggccgtcg tggcgaacgt gaggaacggc aggacgccct ggtcggtacg
    14041 gaccacgttg ccgaccaccg cgaagccggt ccacgcccac cagagcagcg ctagcacgat
    14101 caggcactac accagtccgc gggcggtggg cgtctccgcg gtgagcgtgg tgacccggat
    14161 gaaggcgaag acgaagacca ggtcgtagaa gagttccagg cgggtgacgc gggaaccggg
    14221 cgcgttcggc cacacccctc gcgaccagtg cacccgcccg acatcgccca cctcggcagt
    14281 ctgcccgcca gcaccgctgc ggcggggtcg aatcgacagg tgccggttca ggcgatgacg
    14341 ctcggctccc gccagcgggg cgccccgccc cggtccaggt cgtagcggac cgcggcgatc
    14401 cgtccgaccg cctcgaccag gtcggccgac ggcagggtga acggcagccg caggaaacgc
    14461 tccagggtgc cgtccaggcc gaagcgggga ccgggcgcca gccgtacgcc gacctcctcg
    14521 gccgcccgcg ccagggcgct ggagatcggc ccgtccagct cggcccagag cgtgacgcca
    14581 ccgcgcggca cgctcacccg ccactccggc agccgcgcgg ccagcgcgcc gagcaacgcg
    14641 tcgcgttgtt cggtcagctg cgcccgccgg gcggccacga tggccggcgc ggcggccatc
    14701 aggtgcacgg cgaccagttg gtccagcacc gggctcgcca tgtcgacgcc cacccgggcg
    14761 gcggccagcc gctgcacctg cggggcggag gcgcggatcc agccgatccg cagtccgccc
    14821 cagaacggtt tgctcatgcc gccgatgctg acgacccggg agtgcctgtc gaagctggcg
    14881 gtcggcggcg gcagcacggc gtcgtccagc gacaggtcca cgaacgactc gtcgatcacc
    14941 aggtcggtgc cgaccgcgtg ggcggtggcc accagtcgtt cccgcagctc ggccggcatc
    15001 aggtggccgg tcgggttctg gaagtcgggg atcaggtacg cgacgcgcgg gcgcacctgg
    15061 cgcagcgagc cgagcatcag gtcggcgtcc cagccgtcga gctcggcgga caggccgtgg
    15121 gtggtgatcc gggcccgtcg ggcggcgagc gcggccagcg cgttggggta gctcggcgac
    15181 tcgacaagca cgctgccacc gggggccagt gccagccgca gcaccaggtc cagcgcgtgc
    15241 tgggtgccgt tggtgaccat gatctggtcc ggtgaggtgg gcagcccacg gtcgacgtac
    15301 gcctgtgcca ccgcctcccg cagctcgatg atcccgatcg ggtggtagcc ggccccgccg
    15361 aggtagcgcg gcaggtcctc ggccgccgca cgggcggccg gcagcagctc cggcggtgcg
    15421 gccaacgccg ccacgccgag gtcgagcatc tcccggtcgt ccagcgggat ccacagcccg
    15481 ttgctggcca cccggtgcgt cccgggcagc atcgtccaac tgcccgcgcc gcgccggctg
    15541 gccaggtgcc cgctgtcgcg caactcgcgg taggcggcgg tgacggtggt acggctgatc
    15601 tgcaacgcct cggccaggtc ccgctcggcc ggcaggcgta cgcccagcgg tagccgcccg
    15661 tcggcgagca ggccccgtac ggcaccggcc agcgcggcgt agtccggact gcgtcgacga
    15721 cccgggagcg catgccattg cccgagcagg cgggccaatt gggctccccg cacctgactt
    15781 gtcacagcca ctccccgaat attggctctt caaaggcgcg aattggcccc tagggtggca
    15841 tgcgtgatgc tcattggcaa cctgcgccac cgtccggtcc ggcgcctggt gcaactcttc
    15901 ggcgggctgc tcctctacgg cgccagcatg gctttgatgg tccgctccga actcggcctg
    15961 aacccgtggg acgtgttcca ccagggcgtg tcccgactca ccggcctcag catgggcacg
    16021 gtggtcatcg ccgtcggcct gctggtcctg ctggcctgga tcccgctgcg gcaacggccc
    16081 ggcatcggca ccctcgccaa tgccgtcgtg gtcggcctgg cggtcgacct gaccctggcc
    16141 ctgctgccac cggtggaacc gctcgccgcc cagatcgccc tgctcactgc cgggatcgtg
    16201 ggcaacggta tggccaccgc cctctacctc ggcgcccgcc tcgggcccgg cccccgcgac
    16261 gggctgatga ccggcttcac cgcccgccga cccggaaggt cgctgcgcct ggtccgtacc
    16321 gtcatggagg tcgtggtgct ggccgtgggc gcgctgctgg gcggcaaact cggcgtcggc
    16381 acgatcgcct acgcgctggc catcgggccg ctggcgcagt tcttcctgcc ccggttcgac
    16441 gtgccggagc cgcaccccgg gacgacgaca ccgcggatcg agacggcccc gaccccctga
    16501 caatcactca acgcaaccat cgtcgccgcg cgtccgcgaa cgagagccag gtcaacgtcg
    16561 accattcgag cccgcacatt acgtggcgta acgcatgggt gggtggtgtt ttcatggcac
    16621 cgatcggacg gcagaatctt cacatggggg agaacgcctg gcgtcggacc gatgcatgga
    16681 tcttcgtctc gttggtgatc gccagcggcg cggggcggca ccggcggtct ccgaccaccc
    16741 gccgccccga gggcgtacgc ctggccgacg tgctctccac ggccgaccat ctcgaccaga
    16801 gcatccccga acggcacgac atcgaagagg cgatccggcg gctgctcggc gccggcctgg
    16861 tcgacgtcgc cgacggctgg ttccggatca ccccggccgg ggagcggctc tggcgctccc
    16921 gacccaccgc cgggctggcc accactgtcg acaccgtgca gagcgtgctc gaccgccggc
    16981 acgcgccggg caccgccgaa tggcacctgg atgaggccga gcacgccgcc gccgtgcagg
    17041 aatatctggt gcggaccatc ccgatgcccc ggcagtcccc cgaagggcac tccgggcgca
    17101 gctgaccgcg cagggcgtca gcgaacgggg tgacctgccg tccgcagcgc gtccttgacc
    17161 tcgccgacgg tcagctcacc gaagtggaag acgctggcgg ccagcaccgc gtcggcgccg
    17221 gcgccgatcg ccggcgggaa gtgcgccacc tcgcccgcgc cgccgctggc caccacgggc
    17281 acgtccacca cccggcgtac cgcgccgatc agttcgaggt cgaacccggc cttggtgccg
    17341 tcggcgtcca tggagttgag caggatctca ccggcgccca actccgcgac ccgctgcgcc
    17401 cactgcacgg cgtccagccc ggtgccgcgc cggccgccgt gcgtggtgac ctcgaagccg
    17461 ctcggggtgg tgccggccgg ggcccggcgc acgtccagcg agagcaccag cacctgccga
    17521 ccgaaccggt cggcgatctc ggcgatcaac tcgggccggg cgatcgccgc ggtgttcacc
    17581 ccgaccttgt cggcaccggc acgcagcagg gtgtccacgt ccgcgaccgc ccgcacacca
    17641 ccgccgacgg tcagcgggat gaagaccgac tcggcggtac gccgcaccac gtccagcatg
    17701 gtgccccggt cactggacga ggcggtcacg tcgaggaagg tcaactcgtc cgcgccggcc
    17761 cggtcgtagg ccgccgccaa ctcgaccggg tcaccggcgt cacgcaggtc gaggaagttg
    17821 acgcccttga ccacccgacc cgcgtccaca tcgagacagg ggatcacccg taccgccacc
    17881 gtcatgacca gatcctcact gctcggcgag ggcctggagg gcctccgcga cggtgaaggc
    17941 gccggcgtag agcgccttcc cggcgatcac gccctcgacg ccgatcggtt ccagggtggc
    18001 cagcgcacgc aggtcgtcaa gcgtcgagac tccgccggag gcgatcaccg gcgcgtcggt
    18061 gcgggcgcac acctcccgca gcaggtccag gttcggcccg cgcatggtgc cgtccttggt
    18121 gatgtcggtc accacgtacc gggcggcacc ggccttgtcg agccgctcca gcacctcgta
    18181 caggtcgccg ccgtcgcggg tccagccccg ggccgcgagg gtacggcccc gcacgtccag
    18241 gccgatcgcg acccggtcgc cgtactcgcc gcagatccgg tcacaccact gcggatcctc
    18301 cagggcggcg gtgccgatgt tcacccgggt cgcgccggtg gccagggcgg cacgcaggga
    18361 ggcgtcgtcg cggatgccac cggacaactc cacctgcacg tcgagacggc gcaccacctc
    18421 ggcgagcagt gcggcgttgg aaccccggcc gaacgccgca tccaggtcga ccaggtgaat
    18481 ccactcggcc ccgtcccgct gccacgccag ggcggcctcc agcgggtcgc cgtaggtggt
    18541 ctcgctgccg gcagcgccct gtacgagccg gacggcctgg ccgtcggcga cgtccacggc
    18601 gggcaacaga gtgaggctca cgtgtctttg tccttccaga tcaggaacgg cggtccaggg
    18661 cgaccaccac gatcaccggc agtacgagca gcaacagcac gatcaacacg acgcgcagcg
    18721 ccaggtcggg cacgagcacc cagatcagcg cgatcgccgc cagggtcagc gccacgatgg
    18781 tggcccgttc gcggcgcgag tacctcaaca gacgtcccgt ccgaccccgt cgtacggtcg
    18841 gcaccatccg ccggatcagc gcccggcgtc gggcccggcg ggccagcgcc cgttcccggg
    18901 ccacccgtcg gcgcgccgcc tccgcctccc ggaccgcacg gcggcgggct cgctccttgc
    18961 tcaccgcggc ctccacgaca cccggccgtc ggacccgacc ggtcggccgt tcggttcagc
    19021 catcggtggg tacggtggcc agccagttgc gcagcaacgt ggcaccggtg tcggcggact
    19081 tctccgggtg gaactgggcg gccgacaggg gcccccgctc caccgcggcg acgaaatcgg
    19141 cgtcgtggtg ggcggtggtg acccgggcac cggccgcgag aagtgcggtg gggtcgcaga
    19201 cggcgtacga gtgcacgaag tagaaccggc tgtcggccgg caatccggcg aacagcaccg
    19261 agccgaccgg cggcgcgacg gtgttccagc ccatgtgcgg cagccgggcg gcgggcaacc
    19321 gcgtcacgtt gcccggcagc agacccagcc ccttggtgat cacgccgtgt tcgtcgccgg
    19381 actcgaagag gatctgcatg cccacgcaga tgcccagcac cggacggccg gcggcgaccc
    19441 gcccggcgat caccgggccg gcgccgagcg cctcgatgcc ggccatgcag gcggcgaagg
    19501 caccgacgcc gggcaccacc agaccgtcgg cgtcggccgc ggcgaccagg tcgtcggtga
    19561 ccgtgacgtc ggcaccggcg gcggccaggg cccgctcggc ggaacgcagg ttgcccgagc
    19621 cgtagtcgag caccaccacc cggggccggg gggtgtcgcg gtccgtcacg atccctcccc
    19681 gggcagcagc cacagcaccc cggccacggt ggccagcacc gccagcaggg cggtgaccac
    19741 gacggccccg cgcggggcac cctgccggtg cagggaccag gtcccaccca ccagcacccc
    19801 ggcgaagatc aacagcaggg tcggcaggat cgagctcatc gccgccaccc ccgcccgtac
    19861 cgcccggcgg acatcacagc gcacccttcg tgctggggat gaccccggcc gagcgcggat
    19921 cgatcgcggt ggcctcccgc agggcccggg acaccgcctt gaactgcgcc tccaccacgt
    19981 ggtgggcgtc cgggtgaccg cccggacggg ccgcccgcag cacgtccacg tgcagggtga
    20041 tccgggcagc ctggccgaag gactcccaga tgtgccgggt catgctggtc gggtagaccg
    20101 gcccgatgta cggggtcagc agcggctcgt cgtgcaccac gtacggccga ccggacaggt
    20161 cgacggcggc ccggaccagc acctcgtcca tcgggacggt ggccgagccg taccggcgga
    20221 tgccggcctt gtcccccagc gcctggtcga acgcggcgcc gagcgccagc gcggtgtcct
    20281 ccatcgtgtg gtgcgcgtcg atctccaggt cacccacggt ctggacggtc aggtcgaagc
    20341 cgccgtgccg ggcgatctgg tgcagcatgt ggtcgtagaa gccgaccccg gtgctgatct
    20401 ccgccgctcc ggcgccgtcc aggtcgatct cgaccaggac cttggtctcc ttggtgatcc
    20461 gctccacccg ggcggtccgg ctcatcatgt gcctttcggt cgcggctgcg gggctggcag
    20521 gcccgcgcgc tggatctgat cgatggctgc caggaaggcg tcggtctcgg cgggcgtgcc
    20581 cgcggtcacc cgcagccagc cgggcagccc gacgtcgcgg accagcacac catgatccag
    20641 catcgcctgc caggccaggg tctggtcacc gtcgacggcg tacagcacga agttggcgtc
    20701 gctgtcggcc acccgcagac cacgacgacg cagctcggtg acgatccggt cgcgctgccg
    20761 catgatcgcg gcgaccgtgc cgagcagggc gtcgcggtgc gccagcgcgg cccgggcggc
    20821 agcctgggtg agcgcggaga ggtggtacgg caggcggacc agctgcaccg cgtccaccac
    20881 cgcaggatcg gccgccaggt agcccagccg gccaccggcg aacccgaacg cct
//
