LOCUS       NC_015434              18535 bp    DNA     linear   CON 27-APR-2023
DEFINITION  Micromonospora maris AB-18-032, complete sequence.
ACCESSION   NC_015434
VERSION     NC_015434.1
KEYWORDS    .
SOURCE      Micromonospora maris AB-18-032
  ORGANISM  Micromonospora maris AB-18-032
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP002638.1.
            Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
            Bacteria available from James E.M. Stach (School of Biology Ridley
            Building University of Newcastle, E-mail: jem.stach@ncl.ac.uk).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2023-06-16 18:53:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4751663
            Orig. end    :: 4770198
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..372)
                     /locus_tag="VAB18032_RS20890"
                     /old_locus_tag="VAB18032_25775"
     CDS             complement(1..372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018720866.1"
                     /locus_tag="VAB18032_RS20890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25775"
                     /product="glyoxalase"
                     /protein_id="WP_013734905.1"
                     /transl_table=11
                     /translation="MIHHVQLACPRDSEDRSRAFYVDLLGLTELTKPPTLAARGGCWFS
                     GYGAELHLGVEDDFRPARKAHPALLRPDLDALATRLTAAGCPVTWSDDLPGLRRFHTTD
                     PHGNRLEFLTPTHPTPSPR"
     protocluster    1..18535
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[9237:10140]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9238..10140
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="18"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     gene            532..3387
                     /locus_tag="VAB18032_RS20895"
                     /old_locus_tag="VAB18032_25780"
     CDS             532..3387
                     /EC_number="4.2.1.3"
                     /GO_function="GO:0003994 - aconitate hydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788270.1"
                     /locus_tag="VAB18032_RS20895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25780"
                     /product="aconitate hydratase"
                     /protein_id="WP_043721457.1"
                     /transl_table=11
                     /translation="MKEYDVASLDTFGAKTQLRVGDASYEIFKISQVEGHERLPYSLKI
                     LLENLLRTEDGANITAEHIRQLGAWDPNADPNVEIQFTPARVLMQDFTGVPCVVDLATM
                     REAVRDLGGDPTKVNPLAPAELVIDHSVIADLFGREDAFERNVELEYARNKERYQFLRW
                     GQTAFNEFKVVPPGTGIVHQVNIEYLARTIMERNGQAYPDTVVGTDSHTTMVNGLGVLG
                     WGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGEMPAGTTATDLVLTITEMLRKHGVVGKF
                     VEFYGPGVSAVPLANRATIGNMSPEYGSTVAIFPIDAETVRYLELTGRDASQVALVEAY
                     AKEQGLWHDPAAEPDYSERLELDLSTIEPSLAGPKRPQDRVPLGSAKTLFRAALTDYVA
                     ADETGGDPGREPGVPQQETPFGTAGPADEASAESFPASDSPANGVNDPADAPRDLVTAA
                     VGAGGRASNPIRVTGEDGNTYELDHGAVVIAAITSCTNTSNPQVMIGAALLARNAVDKG
                     LNRKPWVKTTLAPGSKVVMDYYERAGLTPYLEKLGFHLVGYGCTTCIGNSGPLPEEVSA
                     AVNEADLTVVSVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDIDLANEPIGED
                     SEGNPVYLRDIWPSTAEIQDVIASAIGATGFSAAYADVFAGDERWQSLPTPTGDTFAWD
                     GDSTYVRKPPYFEGMAQQPTPVTDIAGARVLAKLGDSVTTDHISPAGSIKADSPAGEYL
                     AAHGVPRHEFNSYGSRRGNHEVMIRGTFANIRLRNQLVPGVEGGYTVNHLTGEQASIYD
                     ASMAYQAADVPLVILAGKEYGSGSSRDWAAKGTMLLGVKAVIAESYERIHRSNLIGMGV
                     LPLQFPAGENADSLGLTGTETFTVTGVTALNDGSTPRTVKVTTDSGVEFDAVVRIDTPG
                     EADYYRHGGILQYVLRRMIAS"
     gene            complement(3467..4069)
                     /locus_tag="VAB18032_RS20900"
                     /old_locus_tag="VAB18032_25785"
     CDS             complement(3467..4069)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012181503.1"
                     /locus_tag="VAB18032_RS20900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25785"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_013734907.1"
                     /transl_table=11
                     /translation="MDYGHSERPSGAVALPTAIKILVAGGFGVGKTTLVGAVSETRPLR
                     TEEVLTESGVGIDDLSGVEAKRTTTVAMDFGRITISDDLVLYLFGTPGQDRFWFVWDEL
                     ALGAIGAVVLADTRRLADCFPSIDYFEGRGTPFLVAVNCFEGARHYRLDEVQAALNLDP
                     EVPVLLCDARQRESAKEVLITLVEHAMKLREARRSAD"
     gene            complement(4050..4436)
                     /locus_tag="VAB18032_RS20905"
                     /old_locus_tag="VAB18032_25790"
     CDS             complement(4050..4436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462630.1"
                     /locus_tag="VAB18032_RS20905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25790"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_013734908.1"
                     /transl_table=11
                     /translation="MTVQGEPADHQWVDDHAGPVVRPYAVTGGRARPVTGTFDLISLVM
                     ATRTDVSPEIGLGPEHLAIVGLCQRMQSVAEIAAHLDLPVGTVRVLLGDLVARSLVQIR
                     EPHGTVGVPDNSIFEAVINGLRAL"
     gene            complement(4442..4864)
                     /locus_tag="VAB18032_RS20910"
                     /old_locus_tag="VAB18032_25795"
     CDS             complement(4442..4864)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072006.1"
                     /locus_tag="VAB18032_RS20910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25795"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_013734909.1"
                     /transl_table=11
                     /translation="MAQKTASSADLTWLLDDLVGRVKQAEHAVALSADGLLMASSQGLS
                     RDDGEHLAAMAAGIQSLARGAGKRFGGGQVQQTIIEMQSSFLFVTAAGRNACLAVLASE
                     DADVGLIAYEMAMLVTRVGKFVASPTRSAEQTNGEK"
     gene            complement(4954..7521)
                     /locus_tag="VAB18032_RS20915"
                     /old_locus_tag="VAB18032_25800"
     CDS             complement(4954..7521)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475909.1"
                     /locus_tag="VAB18032_RS20915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25800"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_013734910.1"
                     /transl_table=11
                     /translation="MGSRSSNLRTKVVALLASLVALWGFTAWVTVREGVNLVGVQALDV
                     RVFDPTEPLLLQLQLERRNSVVYLGRPEESQRAELEKLRQRTDELAGEFVESTDHWQVS
                     LLGSKDLHERIDALNRGLSVLSETRTAVDQRNISRSEAMTAFTELIEAIFEVYDELGNL
                     DDDEVAENTAQLIRLNRARELVSQEDAMLAGILAAGRITQTERAEFTRVVGARQFLAEQ
                     AVVRLPETDQRRYEQMMAGANFTRLANLENQVMLATGTSRPPFDSQKWNEASAAALVEI
                     GDVVLAGGDEIVKRATPVAIGVIVRLVLAAGLGLLAVIASVVVSITTARALVQQLQRLR
                     DAAIQLADERLPSVVERLGRGDQVDVAKEAPPLRFGDDEIGQVGKAFNVVQETAIRTAV
                     EQAELRRAVREVFLSLARRTQALVHRQLTLLDAMERREHDAEELEDLFRVDHLATRMRR
                     NAENLIVLSGSTPGRAWRRSVPMVDVIRGAVGEVEDYTRVTVLPIGGVSLAGRAVGDVI
                     HLLAELIENGLSFSPPHTSVEVRGQLVANGFAIEIEDRGLGMTEEDLAAANHRIVDQSE
                     LNLADASRLGLYVVSRLTDRHGVRVRLKESAYGGTTAVVLIPSNLIIVDGSEPEALAGP
                     DADTSTRSAEPVPGTAVQRSAAPVALAAPAQPPAPRPDRDVDDEHRGADRRAADSPAEV
                     HLSATDTSEGGLPTRSRRRPGHSALDGPTIPISLPVTGSPGPGLPQRPLDTRDQPADVP
                     APAGGAPAATEPGEAGLVESVRTESGLPVRIRQASITPALRAEPEAAEEDEDVIREPEQ
                     VRRMMSSYQTGTRRGRTDAARLLGGGGRPGDADESDGADQQES"
     gene            complement(7631..9241)
                     /locus_tag="VAB18032_RS20920"
                     /old_locus_tag="VAB18032_25805"
     CDS             complement(7631..9241)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072008.1"
                     /locus_tag="VAB18032_RS20920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25805"
                     /product="hypothetical protein"
                     /protein_id="WP_013734911.1"
                     /transl_table=11
                     /translation="MTAPTLTLGAVAAPGLTDAVGDLLAQLEQHPYGQVSTSVYETARL
                     VADAPWVDGHAPRLAYLLAEQGADGSWGPAGGYALVPTASAVQALLASLVRADPPDPAG
                     PGRSEVVAAATRGLAALVRCLGDDAAVPDTPAADLIVPALVARIEAHLTELAGAPTLTD
                     APGALPGVDRRRVDAVNALLTSGRPVPSKLWHAYEVLGPAAATRDDVAPVDGAVGASPA
                     ATAVWLGHRRTDDPAARRYLDAVVARQGGPVPCCTPITVFERSWTLATLARVGLPVDPG
                     ARLLAELAAALGPDGAATGPGLPADADTTSTVLYALARLGRPVDPVSLLHYDLGSHFCT
                     WRGEDGQSVTTNAHVLEALGWHARHGADRYTARVASLAGWLRDVQGPDGLWTDRWHASP
                     YYATCCAVSALAGHAPPEVADTAIDRAVERILADQRDDGGWGRWSSTAEETAYAVQILL
                     GSGRPIRPAVTAAVCRAVGHLRADRSDYPPLWHDKDLYAPILIVRAAVIAARKLVLAVA
                     PTINQALSTTTPEAGRSRA"
     gene            complement(9238..10140)
                     /locus_tag="VAB18032_RS31885"
                     /old_locus_tag="VAB18032_25810"
     CDS             complement(9238..10140)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072009.1"
                     /locus_tag="VAB18032_RS31885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25810"
                     /product="terpene synthase family protein"
                     /protein_id="WP_013734912.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 4.4e-07,
                     bitscore: 28.0, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPLTETPPSIGGDQMSVAAEQGRICALAAKGQRDLAKVAAAYPE
                     LFPAKPFDATLFGNVAMAIAFGAPWCDVAQLRLTNRAVLWGFAVDWLVDHEARARDEID
                     RLTARCLAVADGATPEPGDALGGFLAELRDELATVPAFAAHRDRWREETRKVLAAMARE
                     WDWKQNPDQLPSFEEYLDNADNLACTVVNVVHWIHTADPATLTHLDAMLAASDRVQRIL
                     RLVNDLGTYERDLRWGDLNALLLVPRTEVEQRIAELVAQARQLLDGLRENCPVQADYLA
                     RQIGFSSGFYRSTDFWGVP"
     gene            complement(10137..11507)
                     /locus_tag="VAB18032_RS20930"
                     /old_locus_tag="VAB18032_25815"
     CDS             complement(10137..11507)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 348.6; E-value:
                     9.3e-106)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462640.1"
                     /locus_tag="VAB18032_RS20930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25815"
                     /product="cytochrome P450"
                     /protein_id="WP_050814638.1"
                     /sec_met_domain="p450 (E-value: 3.5e-70, bitscore: 235.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVQTRRAGSVPLRHVLPGLLRDPARALVECGERSGGDIVKLNL
                     GSFRPFLITHPEHLQRVLREKAENYVRAGDGLQWRPLKRLFGDGILSDGEHWTNSRQIL
                     QPLFTARRIDGLVDRLAVAIEESIDELAEPARSGQPVDMGKVQAQVVCSAIMRVFFADK
                     ISVPDAMRIMEAQDAIAWSVMPRILVPWAPLAAPMPGDRTFRRAVQLIDDLLLPTVRAV
                     RDTADEDGDDIISTLWRGRTEDGGRLTERQVRNDTVAMVATTTETTISVLTWLWPHLEQ
                     NPDIATRLYEELDRVVGDQPVRGQHLRELRYTRQVLDELLRLYPIGWLFPRLAVQEDVI
                     GGVRIPAGSTLVVSPLITHRMTQFWDRPEVFDPDRFQPELVRGRPKYAHFPFGGGPHQC
                     IGMHLFYLEATLIVATLLSRYRFRMSRPSIPGIKVAAALRPMDRVEVTLRPVAGVAA"
     gene            11927..12175
                     /locus_tag="VAB18032_RS20935"
                     /old_locus_tag="VAB18032_25820"
     CDS             11927..12175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287422.1"
                     /locus_tag="VAB18032_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25820"
                     /product="DUF2630 family protein"
                     /protein_id="WP_013734914.1"
                     /transl_table=11
                     /translation="MDDKTILSRISELVDEEHRLRADAQATEAGTDDEARTRLRELEAS
                     LDQCWDLLRRRRAARQAHGDPEAQGARPVSEVERYLQ"
     gene            complement(12226..13161)
                     /locus_tag="VAB18032_RS20940"
                     /old_locus_tag="VAB18032_25825"
     CDS             complement(12226..13161)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018583044.1"
                     /locus_tag="VAB18032_RS20940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25825"
                     /product="RIO1 family regulatory kinase/ATPase"
                     /protein_id="WP_013734915.1"
                     /transl_table=11
                     /translation="MRDHDFSARERHTRGKRRFDDDEPQFLKRGRARGPVPADPSDEPD
                     PDTGAVWSSWDDAVHGPQPHPAWLVTDLAAKDTELGVLKTGKEADVHLVRRAVPDSDRS
                     CVLAAKRYRDPRHRLFHRDAGYLEGRRVRRSREMRAMTGRTAFGRQMIAGQWAAAEFAA
                     LARLWEIGERYGTVAVPYPVQLRDTELMLEFLGDPDTGQAAPRLAELRPAGAELRGLWE
                     QLVEALMVLARAGYAHGDLSPYNLLVHAGRLVLIDLPQVVDVVANPQGRDFLARDVRVV
                     STWFAARGLPASLAEPAALTGLLAREAGLR"
     gene            complement(13339..13983)
                     /locus_tag="VAB18032_RS20945"
                     /old_locus_tag="VAB18032_25830"
     CDS             complement(13339..13983)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 56.8; E-value: 4.3e-17)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018583043.1"
                     /locus_tag="VAB18032_RS20945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25830"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_013734916.1"
                     /transl_table=11
                     /translation="MPLLLLDLDNTLLDRAGPFRTWAERFLDGIGAPPADIDWLLSIDA
                     DGLTDRWDVADAIRDRYRLRIPSIDLVEELHDGVVEFTRLDPLVACALRIADGAGWMPV
                     VVSNGAVRQQDAKIRRTGLDRYVADWVISEEAGVSKPNPRIFALAAQRVRMPLRGAWVI
                     GDGPEADIGGATAVGLPSIWLHRGRRWTDARFAPTVTVDTVIAAVAAVMDA"
     gene            14137..14709
                     /locus_tag="VAB18032_RS20950"
                     /old_locus_tag="VAB18032_25835"
     CDS             14137..14709
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 79.7; E-value: 6.1e-24)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018727348.1"
                     /locus_tag="VAB18032_RS20950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25835"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_013734917.1"
                     /transl_table=11
                     /translation="MPRVSQDQLDARRQEILAAARACFARHGYEGATVRRLEEATRLSR
                     GAIFHHFRDKDSLFLAVAEDDAATMVETVARNGLVQVMRDLLARAVSPDTTGWLGSQLE
                     VSRRLRTDPAFAKRWAERSAAIAEATRERLARQRDAGVLREDIPIDVLARFLELAYDGL
                     VLHLAMGRPAGDLGPVLDLVEEAVRRK"
     gene            14799..15725
                     /locus_tag="VAB18032_RS20955"
                     /old_locus_tag="VAB18032_25840"
     CDS             14799..15725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462655.1"
                     /locus_tag="VAB18032_RS20955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25840"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_013734918.1"
                     /transl_table=11
                     /translation="MIEPAADFDFDTWGVPSRTFLIIYLLATVVLIVGVLIFRRRTLTG
                     RSAPPADQLGPQQVAYLTGGEDRAVWSSVSSLRSQGVLGVGPGGELTADGPLSTGATPL
                     DQAVHYAASQRCSARQLRRTEWVTRALDQLRDGLSRHDLLVTPERRAALRLGALLLAAM
                     VALGVARIVAGIANDRPVWYLVFIVGALAVLTTVLFVRVPRRTRAADAALRSLRQRNRH
                     LAPASNPAYAVYGATGAAMAVALYGTASLWALDPTFAQQAEIQREAVTGGGGTVGGSCG
                     GGSTAGASGCGSGDGGGGGCGGGGCGG"
     gene            15722..16540
                     /locus_tag="VAB18032_RS20960"
                     /old_locus_tag="VAB18032_25845"
     CDS             15722..16540
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF692"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018802926.1"
                     /locus_tag="VAB18032_RS20960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25845"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_013734919.1"
                     /sec_met_domain="DUF692 (E-value: 3.1e-81, bitscore: 271.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPHGVGIGWRPEIAGFVAELPGLRFVEVIAESVPTTGPPPDAL
                     VELRQRGVTVVPHGVRLSLGGAEPVEPARVAHLAAVAELLAAPLVSEHIAFVRAGGLEA
                     GHLLPLPRTREAVDAVCANVARAQAELPVPIALEPIAALFDWPDDELDEAAFLSEILAR
                     TDALLLLDIANVHANAVNRGTDPLALLDRLPLERVAYLHVAGGAEQGGFYHDTHTDPVS
                     PAVLDLLTELCARHRPPAVLLERDGRYPPAPELRAELDAVAAATGFPLVT"
     gene            16537..17052
                     /locus_tag="VAB18032_RS20965"
                     /old_locus_tag="VAB18032_25850"
     CDS             16537..17052
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788249.1"
                     /locus_tag="VAB18032_RS20965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25850"
                     /product="hypothetical protein"
                     /protein_id="WP_013734920.1"
                     /transl_table=11
                     /translation="MSAPPVDGTDPTGHRPATPDSRRPPSGSLAARQAELVAALVAGGP
                     PPPGFAPAPLVAARAALLRKRAGEVARHWPLLAAGLAPHWPATFTEWAADRPTLGGLRD
                     GWDLARALHARHALPALGAEELAVREAAYRYDGDAAPRRRRWPAVGRAGAAVAVQLAGR
                     VRLLRTAR"
     gene            17136..17897
                     /locus_tag="VAB18032_RS20970"
                     /old_locus_tag="VAB18032_25855"
     CDS             17136..17897
                     /NRPS_PKS="Domain: PKS_KR (8-151). E-value: 1.8e-08. Score:
                     26.3. Matches aSDomain:
                     nrpspksdomains_VAB18032_RS20970_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     170.4; E-value: 8.3e-52)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018815297.1"
                     /locus_tag="VAB18032_RS20970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25855"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_013734921.1"
                     /transl_table=11
                     /translation="MDLGLTDRVYVLTGASRGLGYATAQCLVADGARVVLSARRADEVA
                     AATAALGGPDRAVGIAADLADPATPGRLVETAQQHFGRLDGALVSVGGPTPGSAASVDD
                     EQWRHAFETVFLGSVRMVRTVAAALPDGGAIALVLSTSARAPVPGLGISNGLRPGLAGV
                     AKDVADEYGPRGVRVVGLLPGRILTDRNRELFAASGDPEQAQAEAEAGIPLRRIGEPAE
                     FGRVAAFVLSPAASYLTGITLPVDGGALRGL"
     CDS_motif       17160..17255
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_VAB18032_RS20970_0001"
                     /evalue="5.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="VAB18032_RS20970"
                     /protein_end="40"
                     /protein_start="8"
                     /score="19.1"
                     /tool="antismash"
                     /translation="VYVLTGASRGLGYATAQCLVADGARVVLSARR"
     aSDomain        17160..17588
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VAB18032_RS20970_PKS_KR.1"
                     /evalue="1.80E-08"
                     /label="VAB18032_RS20970_PKS_KR.1"
                     /locus_tag="VAB18032_RS20970"
                     /protein_end="151"
                     /protein_start="8"
                     /score="26.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VYVLTGASRGLGYATAQCLVADGARVVLSARRADEVAAATAALGG
                     PDRAVGIAADLADPATPGRLVETAQQHFGRLDGALVSVGGPTPGSAASVDDEQWRHAFE
                     TVFLGSVRMVRTVAAALPDGGAIALVLSTSARAPVPGLG"
     gene            17960..18535
                     /gene="mug"
                     /locus_tag="VAB18032_RS20975"
                     /old_locus_tag="VAB18032_25860"
     CDS             17960..18535
                     /EC_number="3.2.2.28"
                     /GO_function="GO:0000700 - mismatch base pair DNA
                     N-glycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006285 - base-excision repair, AP site
                     formation [Evidence IEA]"
                     /codon_start=1
                     /gene="mug"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459870.1"
                     /locus_tag="VAB18032_RS20975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_25860"
                     /product="G/U mismatch-specific DNA glycosylase"
                     /protein_id="WP_043725236.1"
                     /transl_table=11
                     /translation="MTPRPHPRPSREDLAAAVDRTLPDVIGTGLDVLFVGINPGLWSAA
                     TGWHFARPGNRFWPALHRSGFTPRLLHPSEQDSLPELGLGITNIVARASARADELTAAE
                     LVAGARELTGKVARYRPRWVAVVGVTAYRVGFARPKATFGRQPEPLAAAQLWVLPNPSG
                     LNAHYTPETLAAAFAALREATGRQPAGG"
ORIGIN
        1 tcaacgcggc gagggggtgg ggtgggtggg ggtgaggaac tccaggcggt tgccgtgggg
       61 gtcggtggtg tggaagcggc gtaggccggg gaggtcgtcg ctccaggtga cggggcagcc
      121 ggcggcggtg aggcgggtgg ccagggcgtc gaggtcaggt cggagcaggg cggggtgggc
      181 tttgcgagcc gggcggaagt cgtcctcgac gccgaggtgc agttcggcgc cgtacccgct
      241 gaaccagcaa ccgccgcgag cggcgagggt cggtggtttg gtcagttcgg tcaggccgag
      301 caggtcgaca tagaaggccc gggaccggtc ctcggagtcg cgcgggcagg cgagctggac
      361 gtgatggatc atgatgagca cctcccgtcc acacgatgac accgggttgc gctcatagca
      421 agacggacgt acggttttgt tgacagggag aatcggcggt aagtgtcccc taaccacggc
      481 ggcgccccgg ccggtgcgaa agactgctca ggactactca cggtcgctgg tgtgaaggag
      541 tacgacgtgg cgagcctcga caccttcggt gcgaagaccc agctacgcgt cggagacgcg
      601 agctacgaga ttttcaagat cagccaggtg gagggccacg aacggctccc ctacagcctg
      661 aagatcctgc tggaaaacct gctgcggacc gaggacggcg cgaacatcac cgccgagcac
      721 atccgccagc tgggcgcgtg ggacccgaac gccgacccga acgtcgagat ccagttcacc
      781 ccggcgcggg tgctgatgca ggacttcacc ggcgtaccgt gcgtggtcga cctcgccacc
      841 atgcgtgagg ccgtccgcga cctcggcggc gaccccacca aggtgaaccc gttggccccc
      901 gccgagctgg tcatcgacca ctcggtcatc gccgatctgt tcggccgcga ggacgccttc
      961 gagcgcaacg tcgagttgga gtacgcccgc aacaaggagc gctaccagtt cctgcgctgg
     1021 ggccagaccg cgttcaacga gttcaaggtg gtcccgcccg gcaccggcat cgtgcaccag
     1081 gtcaacatcg aatacctggc gcgtacgatc atggaacgca acggtcaggc gtacccggac
     1141 accgtggtcg gcaccgactc gcacaccacg atggtcaacg gcctgggcgt gctgggctgg
     1201 ggcgtcggcg gcatcgaggc cgaggccgcg atgctgggcc agccggtcag catgctgatc
     1261 ccccgggtgg tgggcttcaa gctctccggt gagatgccgg ccggcaccac cgccaccgac
     1321 ctggtgctca ccatcaccga gatgctgcgc aagcacgggg tggtcggcaa gttcgtcgag
     1381 ttctacgggc cgggtgtgag cgcggtgccg ctggccaacc gggccaccat cggcaacatg
     1441 tccccggagt acggctccac cgtggcgatc ttcccgatcg acgccgagac cgtccgctac
     1501 ctggagctga ccggccgcga cgcgtctcag gtcgcgctgg tcgaggcgta cgccaaggag
     1561 cagggcctct ggcacgaccc ggcggccgag ccggactact ccgagcgcct ggagctcgac
     1621 ctgagcacca tcgagccctc cctcgccggt ccgaagcgcc cgcaggaccg ggtgccgctg
     1681 ggcagcgcca agacgctgtt ccgcgccgcg ctgaccgact acgtggccgc cgacgagacc
     1741 ggtggcgacc cgggccgcga gcccggtgtg ccgcagcagg agacgccgtt cggcaccgcc
     1801 ggcccggccg acgaggccag cgccgagtcc ttcccggcca gcgactcccc cgccaacggc
     1861 gtcaacgacc cggccgacgc cccgcgtgac ctggtgaccg ccgcggtcgg cgcgggcggg
     1921 cgggccagca acccgatccg ggtcaccggt gaggacggca acacctacga gctggaccac
     1981 ggcgcggtgg tgatcgccgc gatcacctca tgcaccaaca cctccaaccc gcaggtcatg
     2041 atcggcgcgg cgctgctcgc ccgcaacgcg gtggacaagg gcctcaaccg caagccgtgg
     2101 gtgaagacca ccctggcgcc gggctcgaag gtcgtcatgg actactacga gcgggccggc
     2161 ctcaccccgt acctggagaa gctcggcttc cacctggtcg gctacggctg caccacctgc
     2221 atcggcaact ccggcccgct gccggaggag gtctccgccg cggtgaacga ggccgacctg
     2281 acggtcgtct cggtgctctc cggcaaccgg aacttcgagg gccggatcaa cccggacgtc
     2341 aagatgaact acctggcgtc cccgccgctg gtggtggcgt acgcgctggc cggcacgatg
     2401 gacatcgacc tggccaacga gccgatcggt gaggacagcg agggcaaccc ggtctacctg
     2461 cgcgacatct ggccgagcac cgccgagatc caggacgtga tcgcctcggc gatcggcgcc
     2521 accgggttca gcgccgcgta cgccgacgtc ttcgccggtg acgagcgctg gcagtcgctg
     2581 cccaccccga ccggcgacac cttcgcctgg gacggtgact ccacctacgt gcgcaagccc
     2641 ccgtacttcg agggcatggc gcagcagccg accccggtga ccgacatcgc cggtgcccgg
     2701 gtgctggcca agcttggtga ctcggtgacc accgaccaca tctccccggc cggctccatc
     2761 aaggccgact ccccggccgg cgagtacctc gccgcgcacg gcgtgccgcg gcacgagttc
     2821 aactcgtacg gctcgcgtcg gggcaaccac gaggtgatga tccggggcac cttcgccaac
     2881 atccggctgc gtaaccagct ggtgcccggg gtcgagggcg gctacacggt caaccacctg
     2941 accggcgagc aggcctccat ctacgacgcc tcgatggcct accaggccgc cgacgtgccg
     3001 ctggtcatcc tggccggcaa ggagtacggt tccggctcct cgcgggactg ggcggcaaag
     3061 ggcaccatgc tgctcggcgt gaaggcggtc atcgccgagt cgtacgagcg gatccaccgc
     3121 tccaacctca tcggcatggg cgtcctgccg ttgcagttcc cggccggcga gaacgccgac
     3181 tcgctggggc tgaccggcac cgagacgttc actgtcaccg gggtgaccgc gctcaacgac
     3241 ggctcgaccc cccgtacggt gaaggtcacc accgacagcg gcgtggagtt cgacgcggtg
     3301 gtgcggatcg acaccccggg tgaggcggac tactaccgcc acggcggcat cctgcagtac
     3361 gtgctgcggc ggatgatcgc cagctgacgt ccgacagtcc gaggggctcc ctcccgcgca
     3421 ggcgggaagg agccccttcg gtcgttcagg tgcaggtcga caccgctcag tcggcgctgc
     3481 ggcgggcctc gcgcagcttc atcgcgtgtt ccacaagcgt gatgagcacc tccttggccg
     3541 actcgcgctg ccgggcgtcg cagagcagca ccggaacctc ggggtcgagg ttcaacgcgg
     3601 cctgcacctc gtcgagccgg tagtgccgcg ccccctcgaa acagttcacc gccaccagga
     3661 acggcgtgcc acgcccctcg aagtagtcga tggaggggaa gcagtcggcg agccggcggg
     3721 tgtcggccag caccaccgcg ccgatcgcgc ccagcgccaa ctcgtcccag acgaaccaga
     3781 accggtcctg cccgggggtg ccgaacaggt acagcaccag gtcgtcgctg atggtgatgc
     3841 gaccgaagtc catcgccacg gtcgtcgtgc gcttggcctc gacgccggac aggtcgtcga
     3901 tgcccacccc ggattcggta agcacctcct cggtccgcag tggacgcgtc tcgctgaccg
     3961 cgccgaccag tgtggtctta cccaccccga atccacccgc gaccagaatc ttgatcgccg
     4021 tgggcaacgc gaccgcgccc gacggccgct cagagtgccc gtagtccatt gataaccgcc
     4081 tcgaagatgc tgttgtcggg aacgccgacg gtgccgtgtg gctcccggat ctgaaccaag
     4141 ctgcgcgcca ccaggtcacc gagcagcacc cgcacggtgc cgaccggcag gtcgaggtgg
     4201 gccgcgatct cggcgacgga ctgcatccgc tggcacagac cgacgatcgc caggtgctcc
     4261 gggcccaacc cgatctccgg cgagacgtcc gtccgggtcg ccatcaccag cgagatcagg
     4321 tcgaacgtgc cggtcaccgg gcgagcccgg ccgccggtga ccgcgtacgg gcggaccacc
     4381 ggaccggcat ggtcatcgac ccactggtgg tcggcgggct ctccctgcac cgtcatctgg
     4441 gttacttctc cccgttggtc tgctcggctg atcgtgtcgg cgacgcgacg aacttgccga
     4501 cccgggtgac cagcatggcc atctcgtacg cgatcagtcc gacatccgcg tcctcactgg
     4561 ccaggaccgc gagacaggcg ttgcgaccgg cggctgtgac gaacaggaac gaggactgca
     4621 tctcgatgat cgtctgctgc acctgcccgc cgccgaaccg ctttcccgcg cctcgggcca
     4681 ggctctggat gccggccgcc atcgccgcca ggtgctcgcc gtcgtcgcgg ctgagccctt
     4741 gcgacgaggc catcagcaga ccgtcggcgg acagtgcgac cgcgtgctcg gcctgcttga
     4801 cccggccgac cagatcgtcc agcaaccacg tcaggtcggc actcgaagcc gtcttctgcg
     4861 ccacttcgtc gtcctcttct cccccggctc atcgccgtgc tcatctggtc ctgaccgtcg
     4921 gtcgggcgga tcgccgcacg acctgcaccc cggtcaggac tcctgttggt cggcgccgtc
     4981 agactcgtcc gcgtcgccgg gccgaccgcc accaccgagc agccgggccg cgtcggtgcg
     5041 gccacgccgg gtgcccgtct ggtacgaact catcattcgt cgaacctgtt cgggttcgcg
     5101 gatcacgtcc tcgtcctcct ccgcggcctc aggctcggcc cgcagggccg gcgtgatgct
     5161 ggcctgccgg atgcggaccg gcaggcccga ctcggtgcgg accgactcga ccaggccggc
     5221 ctcaccgggc tcggtcgccg ccggcgcacc gcccgccggg gccggcacat cggccggctg
     5281 gtcacgggtg tcgagtggac gctgcggcag cccgggcccg ggtgacccgg tgaccggcag
     5341 gctgatcgga atggtcggcc cgtccagtgc ggagtgtccg ggtcgacgcc gggacctggt
     5401 cggcagccca ccttcgctgg tgtcggtcgc gctgaggtgg acctccgccg ggctgtcggc
     5461 cgcacgtcgg tccgcgcccc ggtgctcatc gtcgacgtcg cggtcggggc ggggcgcggg
     5521 cggctgtgcc ggggcggcca acgccaccgg cgcggccgac cgctgcaccg cggtccccgg
     5581 caccggctcg gcggaccggg tcgacgtgtc ggcgtccggt ccggcgaggg cctccggctc
     5641 gctgccgtca acgatgatca ggttgctcgg gatcagcacc acggcggtcg tgccgccgta
     5701 cgcggactcc ttgagccgga cccgtacgcc gtgccggtcg gtcaaccggc tcaccacgta
     5761 gaggcccagc cgggaggcgt cggcgaggtt cagttcggac tggtccacga tccggtggtt
     5821 ggcggcggcg aggtcctcct cggtcatgcc cagaccgcgg tcctcgatct cgatggcgaa
     5881 accgttggcg accaactgcc cgcgtacctc gacgctggtg tgcggcgggg agaaggacag
     5941 cccgttctcg atcagctcgg cgagcaggtg gatgacgtca ccgaccgccc ggccggcgag
     6001 cgacaccccg ccgatgggca acacggtgac ccgggtgtag tcctcgacct caccgaccgc
     6061 accacggatc acgtcgacca tcggcacgct gcgtcgccag gcgcggcccg gcgtcgagcc
     6121 ggagagcacg atcaggttct cggcgttgcg ccgcatccgg gtggcgaggt ggtcgacgcg
     6181 gaacaggtcc tccagttcct ccgcgtcgtg ctcccgccgc tccatcgcgt ccagcagggt
     6241 gagctggcgg tgcaccaggg cctgggtacg ccgggccagg ctgaggaaca cctcgcgtac
     6301 cgcccgacgc agctcggcct gttccaccgc cgtacggatg gcggtctcct gcacgacgtt
     6361 gaaggcctta cccacctggc cgatctcgtc gtcaccgaac cgcaacggcg gcgcttcctt
     6421 ggccacgtcc acctggtcac cgcgaccgag ccgctcgacc acgctcggca gccgctcgtc
     6481 ggcgagctgg atcgcggcgt cacgcagccg ttgcagctgc tgcaccaggg cccgcgcggt
     6541 ggtgatcgag acgaccaccg aggcgatgac ggcgagcagg ccgaggccgg cggcgaggac
     6601 cagccggacg atgacgccga tggccaccgg agtggcccgc ttgacgatct cgtcaccacc
     6661 ggccagcacg acgtcgccga tctcgacgag tgcggcggcg gaggcctcgt tccacttctg
     6721 gctgtcgaac ggcgggcgtg aggtgccggt ggcgagcatg acctggtttt ccaggttggc
     6781 cagccgggtg aagttggcgc cggccatcat ctgctcgtaa cggcgctggt cggtttctgg
     6841 cagccggacg accgcctgct ccgcgaggaa ctgtcgggca ccgaccacgc gggtgaactc
     6901 ggcccgctcg gtctgggtga tccgaccggc ggccaggatt ccggcgagca tggcgtcctc
     6961 ctgggacacc agttcccgag cgcggttgag gcggatcagc tgagcggtgt tctcggcgac
     7021 ctcgtcgtca tcgagattgc cgagttcgtc gtagacctcg aagatcgctt cgatcagctc
     7081 ggtgaacgcc gtcatggctt cgctgcggct gatattgcgc tgatcgacgg cggtgcgggt
     7141 ttccgagagc acggacagtc cccggttcag cgcgtcgatt cgctcgtgca gatctttgct
     7201 gccgagcagg ctcacctgcc agtggtccgt ggactcgacg aactcgccgg ccaactcgtc
     7261 ggtacgctgc cgcagtttct ccagctctgc gcgctgtgac tcctccggcc gccccaggta
     7321 gaccaccgag ttgcgccgtt ccagctgcag ttggagcaac agcggctcgg tggggtcgaa
     7381 cacccgtacg tcgagtgcct gcacaccgac gaggttgact ccctctcgga cggtgaccca
     7441 ggcagtgaag ccccagagtg ccaccagcga ggccaatagg gccacgacct tggtacgcag
     7501 attcgaactg cgggaaccca ttacaccgtc cctggccctg agctaattga tcggtcggtc
     7561 agcagcgcgt cacgcacatc gaccccggcg cacgctaaca gcgtcaccgc gccaactcaa
     7621 gcgctggtga tcatgccctg ctccgcccgg cttcaggtgt cgtcgtcgac aaagcctggt
     7681 taatcgtcgg tgccacggca aggaccagtt ttcgcgccgc gatgaccgct gcccggacaa
     7741 tgagaatagg cgcgtacaga tccttgtcgt gccacagagg agggtagtcg gatcggtcgg
     7801 ctcgcaggtg cccgaccgcc cggcacaccg ccgcggtcac cgccggccgg atcggccggc
     7861 cgctgcccag caggatctgc accgcgtacg cggtctcctc cgccgtgctg gaccaccgcc
     7921 cccaaccgcc gtcgtcgcgt tggtcggcca ggatacgctc caccgcacgg tcgatcgccg
     7981 tgtcggccac ctccggtggt gcgtgtccgg ccagcgccga caccgcacag caggtggcgt
     8041 agtacggcga ggcgtgccag cggtccgtcc acaggccgtc cggtccctgc acgtcgcgca
     8101 gccagccggc caacgacgcc acccgggcgg tgtacctgtc ggcgccgtgt cgggcgtgcc
     8161 agcccagcgc ctccagcacg tgcgcgttcg tggtgaccga ctgcccgtcc tcaccgcgcc
     8221 aggtgcagaa gtgactgccc aggtcgtagt ggagcaggct gaccgggtcc accgggcggc
     8281 ccagccgggc gagggcgtac aggacggtcg aggtggtgtc ggcgtcggcg ggcaggcccg
     8341 gcccggtggc cgccccgtcc ggaccgagcg cggcggccag ctcggccagc agtcgcgcgc
     8401 ccgggtcgac cggcagaccc acccgggcca gcgtggcgag cgtccaggac cgttcgaaga
     8461 cggtgatcgg tgtgcagcac ggcaccgggc caccctgccg ggccaccacg gcgtcgaggt
     8521 acctccgggc cgccgggtcg tcggtgcgcc gatggcccag ccacacggcg gtcgcggcgg
     8581 gcgaggcacc caccgcgccg tcgaccgggg cgacgtcgtc gcgggtggcg gcggccgggc
     8641 cgagcacctc gtacgcgtgc cagagcttgc tgggcaccgg ccgaccgctg gtcagcagcg
     8701 cgttcaccgc gtccacccga cgcctgtcga ccccgggcag cgcaccgggt gcgtcggtca
     8761 gcgtcggcgc gccggccaac tcggtcaggt gcgcctcgat gcgcgccacc agggccggga
     8821 cgatcaggtc ggcggccggg gtgtccggca cggccgcgtc gtctcccagg caccggacca
     8881 gtgccgccag ccctcgggtg gccgccgcga cgacctcgct ccggcccggc ccggccgggt
     8941 cgggcggatc agcccggacg aggctggcga gcagcgcctg caccgcactc gccgtcggga
     9001 ccagggcgta cccgccggcc gggccccaac tgccgtcggc accctgctcg gcgagcaggt
     9061 acgccagccg cggcgcgtgt ccgtccaccc acggcgcgtc ggcgaccagc cgagccgtct
     9121 cgtacaccga ggtgctgacc tgcccgtacg gatgctgttc cagctgtgcc agcaggtcac
     9181 cgaccgcatc ggtcagcccg ggcgccgcga ccgcgccgag ggtgagcgtc ggtgccgtca
     9241 cggcaccccc cagaagtcgg tggaacggta gaagccgctg ctgaagccga tctgccgggc
     9301 caggtagtcc gcctgcaccg gacagttctc gcgcagcccg tccagcagct ggcgggcctg
     9361 cgccaccagt tcggcgatgc gctgctcgac ctcggtacgc ggcacgagca gcagggcgtt
     9421 caggtctccc cagcgcaggt cgcgctcgta cgtgccgagg tcgttgacga gccgcagaat
     9481 ccgctgcacc cggtcgctgg cggcgagcat cgcgtccaga tgcgtgaggg tcgccggatc
     9541 ggccgtgtgg atccagtgca cgacgttgac caccgtgcag gccagattgt cggcgttgtc
     9601 gaggtactcc tcgaagctgg gcagctggtc gggattctgc ttccagtccc actcccgggc
     9661 catggcggcg agcaccttgc gggtctcctc ccgccagcgg tcccgatggg cggcgaaggc
     9721 cggcacggtg gccagttcgt cgcgcagttc ggcgaggaag ccgccgaggg cgtcgccggg
     9781 ctccggcgtg gcgccgtcgg ccaccgcgag gcagcgggcg gtcagccggt cgatctcgtc
     9841 gcgtgcgcgg gcctcgtggt ccaccagcca gtcgacggcg aacccccaca gcaccgcccg
     9901 gttggtcagc cgcagctggg cgacgtcaca ccagggtgcg ccgaaggcga tggccatggc
     9961 cacgttgccg aacagggtcg cgtcgaacgg cttggcggga aacagttcgg ggtaggcggc
    10021 ggcgaccttc gccaggtccc gctgaccctt ggcggccagg gcgcagatgc gtccctgttc
    10081 cgcggccacg ctcatctggt cgccgccgat gctcggcggc gtctcggtca acggggtcac
    10141 gccgcgacac ccgccaccgg ccgcagggtg acctcgaccc ggtccatcgg acgcagcgcg
    10201 gcggccacct tgatcccggg gatgctcggg cggctcatcc ggaaccggta ccggctgagc
    10261 agggtggcga cgatcagggt cgcctccagg tagaacaggt gcatcccgat gcactggtgc
    10321 gggccgccgc cgaacgggaa gtgtgcgtac ttggggcgac cgcggaccag ctcgggctgg
    10381 aaccggtccg ggtcgaagac ctcgggtcgg tcccagaact gcgtcatccg gtgagtgatc
    10441 agcggactga ccaccagggt ggagccggcc gggatccgga ccccgccgat gacgtcctcc
    10501 tgcaccgcca gccgggggaa gagccagccg atcgggtaga gccgcagcag ttcgtcgagc
    10561 acctgccggg tgtagcgcag ctcgcgcagg tgctgtccgc gtaccggctg gtcgccgacg
    10621 acccggtcga gttcctcgta gagccgggtg gcgatgtccg ggttctgctc caggtgcggc
    10681 cagagccagg tgagcacgct gatcgtggtc tcggtggtgg tggccaccat cgccacggtg
    10741 tcgttgcgca cctgacgttc ggtcagccga ccaccgtcct cggtgcgccc tcgccacagg
    10801 gtggagatga tgtcgtcgcc gtcctcgtcg gcggtgtccc gcacggcccg gacggtcggc
    10861 agcagcaggt cgtcgatgag ttgcacggcg cggcggaacg tgcggtcacc gggcatcggt
    10921 gcggccagcg gcgcccaggg caccaggatc cggggcatca ccgaccaggc gatggcgtcc
    10981 tgcgcctcca tgatccgcat cgcgtccggc accgagatct tgtccgcgaa gaagacccgc
    11041 atgatcgctg agcagaccac ctgggcctgg accttgccca tgtccaccgg ctggccggat
    11101 cgtgccggtt cggccagctc gtcgatcgac tcctcgatcg ccacggcgag gcggtcgacc
    11161 agcccgtcga tgcgccgggc ggtgaacaac ggctggagga tctgtcgact gttcgtccag
    11221 tgttcaccgt cgctgaggat gccgtcgccg aaaagccgct tgagcggccg ccactggagc
    11281 ccgtcaccgg cccggacgta gttttcggcc ttttcccgca gcacgcgctg gaggtgttcg
    11341 gggtgggtga tgaggaaggg ccggaaggag ccgaggttga gcttcacgat gtcgccaccg
    11401 gaccgctcac cacactccac cagggcgcgg gccggatccc gtagcaggcc tggcaacacg
    11461 tgccgcagcg gcacggatcc ggctcgtcgg gtttggacag tcgtcacgtg gtgtgttccc
    11521 actcgcacag acccccgggg tgtgggttac tcttcgaaat gccacggttg cgatgagcat
    11581 gacatcgata tggcatccgt cactagtcgc gtgctgagaa atcttcatgg tcgacattcc
    11641 cgctgtccac aaccgattta gcgtcgtccg gcgggcaccg gccggtccga tctgacgccg
    11701 ccggccgacc cggcgcgcga cccgaccgtg tccgcccagc tcagcagggc cttcgtgggg
    11761 cagcgaccac ggccaggcac cgatcgatgg ctgtgggttc aggcccggac cgggtgatct
    11821 atttcatgtc cggcatgtaa gtcatcggca ccgcccggcc cgcctcgcca cggctgaccg
    11881 ccggagaatc caggcgtggc ccggctcgct gtgccacgct caggagatgg acgacaagac
    11941 catcctgagc cggatctccg aactggtcga cgaggagcac cggttgcgcg ccgacgcgca
    12001 ggccaccgag gcgggcaccg acgacgaggc acgcacccgg ctccgtgagc tggaggcgtc
    12061 cctcgaccag tgctgggacc tgctccgccg ccgccgtgcg gcgcggcagg cacacggcga
    12121 cccggaggcg cagggtgccc gaccggtgtc ggaggtcgag cggtacctcc agtagcgatg
    12181 gaccggctcc gggtggttgc cgatgccgcc acccggagcc ggccgtcagc gcaggcccgc
    12241 ctcgcgcgcc agcagtccgg tgagcgcggc cggttcggcg aggctcgccg gcaggccacg
    12301 ggccgcgaac caggtgctga cgacccggac gtcacgggcc aggaagtcgc gcccctgcgg
    12361 gttcgccacc acgtccacca cctgtggcag atcgatcagc accagccgcc cggcgtgcac
    12421 cagcaggttg tacggcgaca ggtcgccgtg cgcgtacccg gcccgggcca ggaccatcag
    12481 ggcctcgacc agttgctccc acaacccgcg tagctcggct ccggccggcc gcagttcggc
    12541 cagccgaggg gcggcctgtc cggtgtccgg atcgccgagg aactccagca tcagttcggt
    12601 gtcccgcaac tgcaccgggt acggcaccgc caccgtcccg taccgctcgc cgatctccca
    12661 gagccgggcc aacgcggcga actcggccgc cgcccactgc ccggcgatca tctggcggcc
    12721 gaacgccgtc cgaccggtca tcgcacgcat ctcccgggac cggcggaccc ggcgtccctc
    12781 caggtatccg gcgtcgcggt ggaagaggcg gtgccgggga tcgcggtagc gcttggccgc
    12841 cagcacgcag gaacggtcac tgtcggggac ggcccggcgg accaggtgga cgtccgcctc
    12901 cttgccggtc ttgagcaccc ccagctcggt gtccttcgcg gccaggtcgg tgaccagcca
    12961 ggccggatga ggctgcggac cgtgtacggc gtcgtcccag gaggaccaga cggcgccggt
    13021 gtccgggtcg ggttcgtcgg aggggtcggc cggcaccggg ccgcgcgccc gcccgcgctt
    13081 caggaactgt ggttcgtcgt catcgaagcg gcgtttgccg cgggtgtggc gctctcgcgc
    13141 cgagaaatcg tgatcgcgca cgatgctggt atcccttggt cgaggtgact ggaggcagga
    13201 agtgacctgc gaagacggcc atgaccgacc ccctctcctc gaccgggcga gcgcccgggt
    13261 gcacgatgcg cggaccatgc tcgctgcgcc cctggggcag cgtcaatcgc ttttctcgtc
    13321 accggccgtc ggctggtctc acgcgtccat gacggcggcg accgcggcga tcaccgtgtc
    13381 gacggtgacg gtcggggcga aacgggcgtc cgtccagcgc cgcccccggt gcagccagat
    13441 gctgggcagg ccgacggcgg tcgcgccacc gatgtccgcc tcggggccgt ccccgatcac
    13501 ccaggcacca cgcagcggca tccgcacccg ctgggcggcc agggcgaaga tccgcgggtt
    13561 gggcttgctg accccggcct cctccgagat cacccagtcc gccacgtacc ggtccaggcc
    13621 ggtacgccgg atcttggcgt cctgctggcg taccgccccg ttgctcacca ccaccggcat
    13681 ccagcccgcg ccgtcggcga tccgcaacgc gcaggcgacc aacggatcga gtcgggtgaa
    13741 ctcgacgacc ccgtcgtgca actcctcgac caggtcgatg gaggggatgc gcagccggta
    13801 gcggtcccgg atggcgtccg cgacgtccca gcggtcggtg aggccgtcgg cgtcgatgga
    13861 cagcagccag tcgatgtcgg ccgggggtgc gccgatgccg tcgaggaagc gctctgccca
    13921 ggtgcggaac ggcccggccc ggtcgagcag ggtgttgtcc aggtccagca ggagcagcgg
    13981 cactcgggaa ccctacggta atcgggtacc cgcccgacag ggccggacgt tacgcgctga
    14041 tgacggaccg gggcatgatt cgggttcctg ttcgacagat gtaccaagcc gtacgtacgg
    14101 tttgcataac ccctggtggg ctgggacgat caggatgtgc ccagagtaag tcaggatcag
    14161 ctcgacgccc gccgacagga gattctcgcc gccgcgcggg cctgtttcgc ccggcacggc
    14221 tacgagggcg ccaccgtacg ccgcctcgag gaggcgaccc ggctatcccg aggcgccatc
    14281 ttccaccact tccgcgacaa ggactcgttg ttcctcgccg tcgccgagga cgacgcggcg
    14341 accatggtgg agacggtcgc ccgtaacggt ctggtgcagg tgatgcgcga cctgctcgcc
    14401 cgggcggtct ccccggacac caccggctgg ctgggaagcc aactggaggt gtcccggcgg
    14461 ttgcgtaccg acccggcttt cgccaagcgc tgggcggaac ggtccgcggc catcgccgag
    14521 gcgacccggg agcggctggc ccgccagcgc gacgccggcg tactccgcga ggacatcccg
    14581 atcgacgtgc tggcccgctt cctcgaactc gcctacgacg ggttggtgct gcacctggcg
    14641 atgggacgac cggccggtga cctcggtccg gtgctcgacc tggtcgagga agcggtacgc
    14701 cgcaagtaac gacgaggtaa ccccgcctcg gccaccatcg atcgctggca tcgtcgccgc
    14761 acaatgaagc gcgtcccctc gcccgacagg agctggccat gatcgagccc gcggcagact
    14821 tcgatttcga cacctggggc gttcccagtc gcacctttct gatcatctac ctgctggcca
    14881 ccgtcgtgct catcgtcggc gtgctgatct tccgtcggcg tacgctgacc ggccgctccg
    14941 cgccgcccgc cgaccaactc ggcccgcagc aggtcgccta cctcaccggc ggggaggacc
    15001 gggccgtctg gtcctcggtc agcagcctgc gcagccaggg cgtgctcggc gtaggccctg
    15061 gcggcgagct caccgccgac ggcccgctgt cgaccggtgc cactccactc gaccaggccg
    15121 tgcactacgc ggccagccag cgctgctccg cccggcaact gcggcgtacc gaatgggtga
    15181 cccgagcact cgaccaactg cgcgacggtc tgtcccgcca cgacctgctg gtcaccccgg
    15241 aacgccgggc ggcgctgcgg ctgggcgccc tgctgctggc cgcgatggtg gcgctcggcg
    15301 tggcacggat cgtcgccggc atcgccaacg accgtccggt gtggtacctc gtgttcatcg
    15361 tcggcgcgct ggcggtgctg accacggtgc tgttcgtccg ggtgccccgc cggacgaggg
    15421 ccgccgacgc cgcgttgcgc agcctgcggc aacgcaaccg ccacctcgcg cccgcctcga
    15481 accctgcgta cgccgtctac ggagccaccg gagccgccat ggccgtcgcg ctctacggca
    15541 ccgcctcgct ctgggcgctg gacccgacct tcgcccagca ggccgaaatc cagcgtgagg
    15601 cggtgacggg cggcggaggc acggtgggcg gcagctgcgg cggaggcagc accgccggcg
    15661 cgagcggctg tggcagcggt gacggcggtg gtggtggctg cggcggcggt gggtgtggcg
    15721 gatgaccggc ccgcacgggg tgggcatcgg ctggcgaccc gagatcgccg ggttcgtcgc
    15781 cgaactgccc ggcctgcgct tcgtcgaggt gatcgccgag tcggtgccca ccaccggtcc
    15841 gccgcctgac gcgcttgtcg agttgcgaca gcgcggcgtg accgtcgtac cgcacggggt
    15901 gcggctctcc ctcggcgggg ccgagccggt cgaaccggcc cgggtggccc acctggcggc
    15961 ggtcgccgaa ctgctggccg cgccactggt cagcgagcac atcgccttcg tccgggccgg
    16021 cgggctggag gcggggcacc tgctgccgct gccgcgtacc cgtgaggcgg tagacgcggt
    16081 ctgcgccaac gtcgcgcggg cccaggccga actgccggtg ccgatcgcgt tggagccgat
    16141 cgcggcgctg ttcgactggc ccgacgacga actcgacgag gcggcgttcc tcagcgagat
    16201 cctggcccgc accgacgcgc tgctgctgct cgacatcgcc aacgtgcacg ccaacgccgt
    16261 caaccggggc accgacccgc tcgccctgct ggaccgcctc cccctggaac gggtggcgta
    16321 cctgcacgtg gccggcggcg ccgagcaggg tggcttctac cacgacacac acaccgatcc
    16381 ggtgtccccg gcggtgctgg acctgctcac cgagctgtgc gcgcggcacc gcccaccggc
    16441 ggtgctgctg gaacgcgacg ggcgctaccc acccgccccc gagctccgtg ccgagttgga
    16501 tgccgtggcc gccgccaccg gcttcccgct ggtcacatga gcgccccgcc cgtcgacggc
    16561 acggatccca ccggccaccg cccggccaca cccgacagcc gccggccacc gtccggatcg
    16621 cttgccgcac ggcaggcgga actcgtcgcg gcgctggtgg ccggcgggcc gccaccgccg
    16681 ggcttcgcgc cggccccgtt ggtcgctgcc cgggccgcgt tgctgcgcaa gcgggccggt
    16741 gaggtggcac gccactggcc gctgttggcc gcagggctcg ccccgcactg gccggcgacc
    16801 ttcaccgagt gggcggcgga tcgacccacc ctcggcgggc tccgtgacgg ctgggacctg
    16861 gcccgcgcgt tgcacgcccg ccacgcgctg ccggcgctcg gcgccgagga actggccgtc
    16921 cgcgaggcgg cctaccgcta cgacggggac gcggcaccgc gccgccgccg gtggcccgcc
    16981 gtcggccggg ccggcgcggc cgtcgccgtg caactcgccg gtcgggtacg cctgcttcgc
    17041 accgcccggt agcagcgccg acaccgcctg ccgcagcgca cccggacgca acccccggtc
    17101 gctcggcgcg ggcgcgctgc ggcaggatcg gcggtatgga tctgggactg accgaccggg
    17161 tgtacgtgct caccggcgcc tcccgtggcc tcggctacgc caccgcgcag tgtctggtgg
    17221 ccgacggtgc ccgggtggtg ctctcggcgc gacgcgccga cgaggtggcc gccgccaccg
    17281 cggccctcgg cgggccggac cgggccgtcg gcatcgccgc cgaccttgcc gacccggcca
    17341 cccccggccg gctggtggag acggcgcagc agcacttcgg ccggctcgac ggggccctgg
    17401 tctcggtggg cgggccgacg ccgggcagcg ccgcctcggt cgacgacgag cagtggcggc
    17461 acgccttcga gacggtcttc ctgggcagcg tacggatggt gcggacggtc gccgcggcgc
    17521 tgcccgacgg cggcgcgatc gcgctggtgc tgtccacctc ggcccgtgcg ccggtgcccg
    17581 gtctgggcat ctccaacggc ctgcggccag ggctggccgg ggtggccaag gacgtcgccg
    17641 acgagtacgg ccctcgcggc gtacgggtgg tcggactgct gccgggacgc atcctcaccg
    17701 atcgcaaccg ggaactcttc gccgccagcg gcgacccgga acaggcccag gccgaggcgg
    17761 aggcgggcat cccgctgcgg cgcatcggcg agccggcaga gttcgggcgg gtcgccgcgt
    17821 tcgtgctctc ccctgccgcg agctacctca ccgggatcac cctcccggtc gacggtggcg
    17881 cgctgcgcgg cctgtgaccg tcgaaccgcc cgccgagcag caccgcaagg cccgacgcgg
    17941 caccgggtcg ggtgcggcgt tgacaccccg cccgcatcca cgtcccagcc gcgaagacct
    18001 ggccgcggcc gtcgacagga cgttgccgga tgtcatcggc accgggctgg acgtgctgtt
    18061 cgtgggcatc aacccggggc tgtggtcggc ggccaccggt tggcacttcg cccgcccggg
    18121 caaccggttc tggccggcgc tgcaccgcag cggcttcacc ccgcgtctgc tgcaccccag
    18181 tgagcaggac agcctgcccg aactcgggct gggcatcacc aacatcgtcg cccgggccag
    18241 cgcccgggcc gacgagctga ccgccgccga actggtggcc ggtgcgcggg agttgaccgg
    18301 caaggtcgcc cgctaccggc cgcgctgggt ggcggtggtc ggggtgaccg cgtaccgggt
    18361 ggggttcgcc cgaccgaagg cgaccttcgg tcggcagcct gagccgctgg ccgccgccca
    18421 gctctgggtg ttgcccaatc cgagcggtct gaacgcgcac tacacgccgg aaaccctcgc
    18481 ggcggcgttc gccgccctcc gcgaggccac cggcagacag cccgccggcg ggtag
//
