LOCUS       NC_015434              11797 bp    DNA     linear   CON 27-APR-2023
DEFINITION  Micromonospora maris AB-18-032, complete sequence.
ACCESSION   NC_015434
VERSION     NC_015434.1
KEYWORDS    .
SOURCE      Micromonospora maris AB-18-032
  ORGANISM  Micromonospora maris AB-18-032
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP002638.1.
            Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
            Bacteria available from James E.M. Stach (School of Biology Ridley
            Building University of Newcastle, E-mail: jem.stach@ncl.ac.uk).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2023-06-16 18:53:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3486653
            Orig. end    :: 3498450
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11797
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:6797]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6797
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     cand_cluster    1..11797
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11797
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="12"
                     /rules="IucA_IucC"
                     /tool="antismash"
     gene            424..1455
                     /locus_tag="VAB18032_RS15475"
                     /old_locus_tag="VAB18032_20245"
     CDS             424..1455
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 92.5; E-value:
                     3.6e-28)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018215730.1"
                     /locus_tag="VAB18032_RS15475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20245"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_013733804.1"
                     /transl_table=11
                     /translation="MPDPVSARRLSRRGLLAAGGAAALAAVLVGCGRDEADKASTSNGS
                     GSWSFTDDRPEAVTAPARPARVVAFTGSAAALVDFGLGREVVGVFGETKKADGSKEPQA
                     GDLDVESVEILGNVWGEFSVEKYAALRPELLVTHMYDPGAYWYVPDESKDKILPLAPVV
                     TITTARVPMTKPIERYAALAQSLGADLSAPKVTDAKARFEAAAEAVRQAVKANPGIKVL
                     AASGSPDLFYVSNPKVSTDLMYFAELGVDIVVPTKLESGDYFEALSWENAGKFPADLIL
                     LDNRSTALQPADLAAKPTWTQLPAVQAGQVTGWDAVPRFSYAGAAPLLEDLAKAIQGAK
                     KLT"
     gene            1596..3113
                     /locus_tag="VAB18032_RS15480"
                     /old_locus_tag="VAB18032_20250"
     CDS             1596..3113
                     /NRPS_PKS="Domain: Aminotran_5 (145-286). E-value: 6.9e-09.
                     Score: 26.9. Matches aSDomain:
                     nrpspksdomains_VAB18032_RS15480_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 372.6;
                     E-value: 4.2e-113)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285762.1"
                     /locus_tag="VAB18032_RS15480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20250"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_013733805.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.2e-06, bitscore:
                     23.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPVHTVTPPSAARAHLFHDGTVDDYRAAVTAGADRVARRVTEA
                     TGPFTGVRPEQLAPLVDAIDLDRPLRDTTAALDELDEVYLRDAVWFHHPRYLAHLNCPV
                     VIPALLGEAVLSAVNSSMDTWDQSAGATLIERRLIDWTAARIGLGPAADGVFTSGGTQS
                     NLHALLLAREEALAGASPTDRRILLPRLRIITSAAGHFSVQKAAKLLGLAPDAVVVVQT
                     GPDRRMRAGAVRHEISRCRRAGLTVLAVVATAGTTDFGTIDPLDEIAEVCATSGAWLHV
                     DAAYGCGLLVSPTRRHLLDGIERADSVTVDYHKSFFQPVSSSAVLVRDRRTLRHATWHA
                     DYLNPARMVAERIPNQVDKSLQTTRRFDALKLWLTLRVMGPDAIGELFDEVCDRAAQAW
                     QLAAADPRFEVLTASALSTVVFRWRPAGTPADLADAANLHARSALAASGLAVVAGTKVD
                     GRQYLKFTVLNPATSPDDVAYVLDLIAEHAGRYAPNTSTLELPCPVG"
     aSDomain        2031..2453
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_VAB18032_RS15480_Aminotran_5.1"
                     /evalue="6.90E-09"
                     /label="VAB18032_RS15480_Aminotran_5.1"
                     /locus_tag="VAB18032_RS15480"
                     /protein_end="286"
                     /protein_start="145"
                     /score="26.9"
                     /tool="antismash"
                     /translation="IGLGPAADGVFTSGGTQSNLHALLLAREEALAGASPTDRRILLPR
                     LRIITSAAGHFSVQKAAKLLGLAPDAVVVVQTGPDRRMRAGAVRHEISRCRRAGLTVLA
                     VVATAGTTDFGTIDPLDEIAEVCATSGAWLHVDAAYG"
     gene            3149..4429
                     /locus_tag="VAB18032_RS15485"
                     /old_locus_tag="VAB18032_20255"
     CDS             3149..4429
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 409.4;
                     E-value: 2.5e-124)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018803066.1"
                     /locus_tag="VAB18032_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20255"
                     /product="SidA/IucD/PvdA family monooxygenase"
                     /protein_id="WP_013733806.1"
                     /transl_table=11
                     /translation="MRSYDVIGIGLGPYNLGLACLTAPIAEIDALFLEARDDVSWHPGM
                     LLESSRLQTPFLADLVTLADPTSPFSFLAYLKEIGRLYPFYIRESFFPLRAEYDAYCRW
                     AAAKLPNLRFGHQVSTVEYDPTSEQYVVTATVGGDTVTHRARHLVLGTGTPPYLPEACA
                     GLDSDAVHNSRYLEHRDALRAKRSITIVGSGQSAAEIYHDLLSDIGTYGYQLNWVTRSP
                     RFFPLEYTKLTLEMTSPDYVDYFHALPEQTRYDLEAEQKGLFKGISADLVNDIFDLLYA
                     TSVPGPVNTRLLTNTELTGVDHDRSTGRHTLRLRHVEQGREHTLDTEGLVLATGYRYQV
                     PAFCDPIRDRLRFDAHGRLDVARNYSVDHTGRGIFLQNGGTHTHSITSPDLGMGPYRNS
                     WIIRELVGREVYPIEKSITFQEFGVPA"
     gene            4426..5004
                     /locus_tag="VAB18032_RS15490"
                     /old_locus_tag="VAB18032_20260"
     CDS             4426..5004
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     147.2; E-value: 1.5e-44)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018807840.1"
                     /locus_tag="VAB18032_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20260"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_013733807.1"
                     /transl_table=11
                     /translation="MSATVHIRTDPVLGEFALRTLDVAADAPLLHGWVTHPKAAFWLMQ
                     DADLAAVVQEYQRIAAHPHHDAFLGLWRGEPAFLAERYDPAQVELVGLYDAQPGDVGMH
                     FLCAPAETPVHGFTRAVITTVMSWLFADPDTVRVVVEPDVRNTAVHALNAAVGFEVIGP
                     ITKPEKQALLSICTRERFLAATRDQGATL"
     gene            5001..6797
                     /locus_tag="VAB18032_RS15495"
                     /old_locus_tag="VAB18032_20265"
     CDS             5001..6797
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007461032.1"
                     /locus_tag="VAB18032_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20265"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_013733808.1"
                     /sec_met_domain="IucA_IucC (E-value: 3.3e-80, bitscore:
                     267.6, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTDPVAHLRPQTWERANRLLVRKALAEFAHERLITPEPDGLAA
                     GGRRWYTVTSDCGTVRYRFTARLRTLEHWDIDPESITRQRDGQPQPLDAVDLCLDLRTS
                     LGLTDRILPVYLEEISSTLAGSAYKLDRALPSAAKLIEADFQTIETSMTEGHPCFVANN
                     GRLGFGVDEYHSYAPEAARPVRLIWLAAHRDHATFTSAADLDYDTLLRTELGEATLARF
                     AETMAALDLDLADYLLIPVHPWQWWNKLSVTFAGEVARRRLVHLGESDDDYLAQQSIRT
                     FFNVSAPHRHYVKTSLSVLNMGFMRGLSAAYMEATPAINDWLADLITADEVFQATGLTI
                     IRERAAVGYRNRQYEAATDRYSPYRKMLAALWRESPVPTLAPGERLATMASLLHVDADG
                     RSFAAELITASGLAPAQWLRRYLHAYLTPLLHAFYAYDLAFMPHGENVILVLRDHAVQR
                     VIFKDIAEEIVVMNTEAALPPAVERIRAEVPEEMKLLSIFTDVFDCFFRFLGATLADQG
                     IADEETFWRTVADCATDYAARVPHLADRLARYDLFAPEFALSCLNRLQLRDNQQMVDLA
                     DPSAALQLVGALTNPLARHAPS"
     gene            6937..7521
                     /locus_tag="VAB18032_RS15500"
                     /old_locus_tag="VAB18032_20270"
     CDS             6937..7521
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 126.4;
                     E-value: 1.5e-38)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018217582.1"
                     /locus_tag="VAB18032_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20270"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_013733809.1"
                     /transl_table=11
                     /translation="MTAQLRRRIRAGDTDAFGELFDEHADAVHRHAVWSEGDPVLAEDV
                     VSLTFLEAWRIRESLRPDGESLRPWLLGIATNVLRNRRRAARRHRAALRRLPVRDTVPD
                     FADDVVGRMHDADQLAAAVAALRALRRADREVFLLCVWSQLDYAAAAEALGVPVGTVRS
                     RLSRARTRLRALAQQELDRPRGTPVEQGEYR"
     gene            7518..8438
                     /locus_tag="VAB18032_RS15505"
                     /old_locus_tag="VAB18032_20275"
     CDS             7518..8438
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018217583.1"
                     /locus_tag="VAB18032_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20275"
                     /product="CU044_5270 family protein"
                     /protein_id="WP_043720824.1"
                     /transl_table=11
                     /translation="MSEPTVPHVPAMATAHRQALRRHLMNEITRPARRPKRTPVLAGAV
                     GVLAAVIAAGTIALPGVPQSAPLVVTVQQAEPAAATTLLNAMAAAVVEKPEPGDGRYVY
                     IRSLGAYAELGGGPARLRPVREREIWIPRYEPGDGLLRQPFFELPVIGVIPERVTLTDM
                     TPNAAVVDLPDDPDELLAKLYRERAERGHGSSRDGAAFTAIGDILRESLVPPQTSAALY
                     RAAARIPGVEVIRQVTDAAGRRGTAVAYTERDRRDEWIFDERTFEYLGSRSYLVADTAD
                     GPAGTVLATTAVLQRAVVPKLGQRP"
     gene            complement(8478..9482)
                     /locus_tag="VAB18032_RS15510"
                     /old_locus_tag="VAB18032_20280"
     CDS             complement(8478..9482)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007462874.1"
                     /locus_tag="VAB18032_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="VAB18032_20280"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_148272283.1"
                     /sec_met_domain="APH (E-value: 3.4e-16, bitscore: 58.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPLSPTQQVLSPDDVADYIAASFGADRQVADCGPLTGGGFATVW
                     WVRLDDGADVVLKVGPPSHVPLLRYETGMLAAEARYFRLVAARAPQVPVPPVLHHGRDA
                     RLGEWLVTGRLPGRALPDLDGADAGARYDFGATVATLHRITGDRFGYDAGRAGGITWSV
                     AFAAIVDDLLADAVDWNVTLPAPPQRFREVVARHAGLLDQVRRPALLHFDGWDGNVLAA
                     PDAHGAYRMCGLVDGERFLYGDPMLDLVSPLLFRRAEDEPEHPFLHGYADAVGTPLVFD
                     DRVRRRLALYRMHLHLLMTVEMPSRGITVDNDPGRHTLLAELLDRDLADLSAE"
ORIGIN
        1 cgggtcagcg cctgcatcgc cgcaccggcc gtgccgagcg ccaggccggc gagcagcccg
       61 agcagggttc ggggcaggcg catgtcgtgc acgacggcgt agtcgacggc acccggatcg
      121 gtgagggccg cccacacctg ggtcagcggg atcggtttgg cgccgacggc gatgctgagc
      181 accaccacga cgaccagagc cagtgcggcg acggcgaggc cggcggcgcg tgacgcggca
      241 tgacctgccc gcggcggtgg ttggtcccgc agtggtgtcg cggcgggagg cgactcggtg
      301 acggacagtg tgaactccag tgcggtgcga aacgccgtgc gggacttgac aggcagttag
      361 gttaggttag cctaaccgcg gctgtccatg gccatccgca caccctgatc ggaagacgac
      421 accatgcctg atcccgtttc cgcccgccgc ctctcccgtc gcggcctgct cgccgccggt
      481 ggcgccgccg ccctcgccgc tgtgctcgtc ggctgcgggc gggacgaggc cgacaaagcc
      541 agcaccagca acggttccgg gtcgtggtcg ttcaccgacg accgcccgga ggcggtcacc
      601 gctccggcgc ggcccgcccg ggtggtggcc ttcaccggct cggcagccgc cctggtcgat
      661 ttcggactcg ggcgcgaggt ggtcggtgtc ttcggcgaga cgaagaaggc cgacggcagc
      721 aaggaaccac aggccggcga cctggacgtg gagagcgtgg agatcctcgg caacgtctgg
      781 ggcgagttca gcgtcgagaa gtacgcggcg ctgcgcccgg aactgctcgt cacccacatg
      841 tacgacccgg gcgcctactg gtacgtgccg gacgagagca aggacaagat ccttccgctc
      901 gcgccggtgg tcaccatcac caccgcccgc gtcccgatga ccaagccgat cgaacggtac
      961 gccgcactcg cccagtccct cggcgccgac ctgtcggcac cgaaggtcac cgacgccaag
     1021 gcgcgcttcg aggccgccgc cgaggcggta cgccaggcgg tcaaggccaa ccccggcatc
     1081 aaggtgctgg ccgcctccgg cagcccggac ctgttctacg tctccaaccc gaaggtcagc
     1141 accgacctga tgtacttcgc cgaactcggc gtcgacatcg tggtgcccac caagctggag
     1201 tccggtgact acttcgaggc gctcagctgg gagaacgccg gcaagttccc ggccgacctg
     1261 atcctgctcg acaaccgcag caccgccctg caaccggccg acctggccgc caagcccacc
     1321 tggacgcagt tgcccgccgt gcaggccggc caggtgaccg gatgggacgc ggtgccccgc
     1381 ttctcgtacg ccggggccgc cccgctgctc gaagacctcg ccaaggcgat ccagggcgcg
     1441 aagaagctga cctgacccgc cacggacgac cggcgtgacc tgagaccgcc ggtcgtccgc
     1501 ccaccaccct catcgacgcc aacccgccgc gcgctgcgcg ggcggcgggt tccggctgcc
     1561 cggaaaccga accgccgagc gtggaggaca cgtccatgac cctgccggtg cacaccgtga
     1621 caccgccgag cgccgcccga gcccacctgt tccacgacgg cacagtcgac gactaccggg
     1681 ccgcggtgac agccggtgcc gaccgggtgg cccggcgcgt caccgaggcg accggaccgt
     1741 tcaccggcgt acgcccggag cagctggcgc cgctggtgga cgcgatcgac ctggaccggc
     1801 cgctgcgcga caccaccgcc gccctcgacg aactcgacga ggtgtacctg cgcgacgctg
     1861 tctggttcca ccacccgcgc tacctggccc acctcaactg cccggtggtc atcccggccc
     1921 tgctcggcga ggccgtgctc agcgccgtga actcctcgat ggacacctgg gaccagagcg
     1981 ccggcgccac cctgatcgag cgacgcctga tcgactggac cgccgcccgg atcggtctcg
     2041 gcccggccgc cgacggggtg ttcaccagcg gcggcaccca gtccaacctg cacgcgctgc
     2101 tgctggcccg ggaggaggcc ctggcgggtg cgagcccgac cgaccggcgg atcctgctgc
     2161 cccgcctgcg gatcatcacc tctgccgcgg gccacttcag cgtgcagaag gccgccaagc
     2221 tgctcggcct ggccccggac gcggtcgtgg tggtgcagac cggcccggac cggcggatgc
     2281 gtgccggtgc cgtccgccac gagatcagcc gctgccggcg ggccggcctg accgtgctcg
     2341 cggtggtcgc caccgccggc accaccgact tcggcaccat cgacccgctc gacgagatcg
     2401 ccgaggtgtg cgccacctcc ggcgcctggc tgcacgtcga cgccgcgtac ggctgcgggt
     2461 tgctggtctc gccgacccgc cggcacctgc tcgacggcat cgaacgggcc gactcggtga
     2521 ccgtcgacta ccacaagtcg ttcttccagc cggtcagctc cagcgctgtg ctggtccgcg
     2581 accggcgtac gctgcggcac gccacctggc acgccgacta cctcaacccg gcccggatgg
     2641 tcgccgaacg catccccaac caggtcgaca agtccttgca gaccacccgc cgcttcgacg
     2701 ccctcaagct ctggctgacc ctgcgggtga tgggccccga cgccatcggc gaactgttcg
     2761 acgaggtctg tgaccgggcc gcccaggcgt ggcagctggc cgccgccgac ccccggttcg
     2821 aggtgctgac cgcgtcggcg ttgagcacag tggtgttccg ctggcggccc gccggcaccc
     2881 cggcggacct ggccgacgcg gcgaacctgc acgcccggtc cgcgctggcc gcctccggcc
     2941 tggccgtggt cgccggcacc aaggtcgacg gccggcagta cctcaagttc acagtcctca
     3001 acccggcgac cagccccgac gacgtggcgt acgtgctcga cctgatcgcc gaacacgccg
     3061 gccggtacgc gcccaacacg tccactttgg agcttccttg tccagtgggc tgagcaggtc
     3121 gacgcagaaa ccgagcatgg agggccgaat gagaagctac gacgtcatcg ggatcggcct
     3181 ggggccgtac aacctgggtc tggcctgcct gaccgcgccg atcgccgaga tcgacgcgct
     3241 gttcctggag gcccgcgacg acgtctcctg gcaccccggc atgctgctgg agtcgtcccg
     3301 gttgcagacc ccgttcctgg ccgacctggt caccctggcc gaccccacct cgccgttctc
     3361 cttcctcgcc tacctcaagg agatcggccg cctctacccc ttctacatcc gggagagctt
     3421 cttcccgctg cgcgccgagt acgacgcgta ctgccggtgg gccgcggcga agctgcccaa
     3481 cctgcgcttc ggtcaccagg tcagcaccgt cgagtacgac ccgacgagcg agcagtacgt
     3541 ggtgaccgcc acggtcggcg gcgacaccgt cacccaccgg gcccggcacc tggtgctcgg
     3601 caccggcacc ccgccgtacc tgccggaggc ctgcgccggg ctggactccg acgcggtgca
     3661 caactcccgc tacctggaac accgtgacgc gctgcgcgcc aaacgcagca tcaccatcgt
     3721 cggcagcggg cagagcgccg ccgagatcta ccacgacctg ctctccgaca tcggcacgta
     3781 cggctaccag ctgaactggg tgacccgctc accccggttc ttcccgctgg aatacaccaa
     3841 gctgaccctg gagatgacct caccggacta cgtggactac ttccacgccc tgcccgagca
     3901 gacccgctac gacctggagg ccgagcagaa ggggctgttc aagggcatct ccgccgacct
     3961 ggtcaacgac atcttcgacc tgctctacgc cacgagcgtg cccggcccgg tgaacacccg
     4021 actgctgacc aacaccgagt tgaccggggt cgaccacgac cggtccaccg gccggcacac
     4081 cctgcggctg cgccacgtcg agcagggacg tgagcacacc ctggacaccg aggggctggt
     4141 gttggccacc ggctaccgct accaggtgcc cgccttctgc gacccgatcc gcgaccggct
     4201 gcgcttcgac gcccacggcc gcctcgacgt ggcccgcaac tacagcgtcg accacaccgg
     4261 gcgggggatc ttcctccaga acggcggcac ccacacgcac agcatcacct caccggatct
     4321 cggcatgggt ccgtaccgca actcgtggat catccgggag ctggtcggcc gggaggtgta
     4381 cccgatcgag aagtcgatca ccttccagga gttcggggtg cccgcatgag cgccaccgtg
     4441 cacatccgga ccgatccggt gctgggggag ttcgccctgc gtacgctcga cgtggccgcc
     4501 gacgcgccgc tgctgcacgg ctgggtgacc caccccaagg cggcgttctg gctgatgcag
     4561 gacgccgacc tggccgcagt ggtgcaggaa taccagcgca tcgccgcgca tccgcaccac
     4621 gacgccttcc tcgggctgtg gcgcggcgag ccggccttcc tcgccgaacg gtacgacccg
     4681 gcccaggtcg agttggtcgg gctctacgac gcccagcccg gtgacgtggg catgcacttc
     4741 ctctgcgcgc ccgccgagac cccggtgcac ggcttcaccc gcgccgtgat caccaccgtg
     4801 atgtcgtggc tgttcgccga ccccgacacc gtccgggtgg tggtcgagcc ggacgtccgc
     4861 aacaccgccg tgcacgccct gaacgcggca gtcggtttcg aggtgatcgg cccgatcacc
     4921 aagccggaga agcaggccct gctgagcatc tgcacccgcg agcggttcct cgccgcgacc
     4981 cgtgaccaag gagcaacgct gtgaccacca ccgacccggt cgcccacctg cgcccgcaga
     5041 cctgggagcg ggccaaccgg ctgctggtgc gcaaggcgct ggccgagttc gcccacgagc
     5101 ggctgatcac ccccgagccg gacggcctcg ccgccggagg ccgccgctgg tacacggtga
     5161 caagcgactg cggcaccgtc cgctaccggt tcaccgcccg gctgcgcacc ctggagcact
     5221 gggacatcga cccggagagc atcacccggc agcgcgacgg ccagccgcag cccctcgacg
     5281 ccgtcgacct ctgcctggat ctgcgcacct cgctcggcct caccgaccgg atcctgccgg
     5341 tctacctgga ggagatcagc tccaccctgg ccggcagcgc ctacaagctg gaccgggccc
     5401 tgccctcggc ggcgaaactg atcgaggccg acttccagac catcgagacg tcgatgaccg
     5461 agggacatcc ctgcttcgtg gccaacaacg gccgcctcgg cttcggcgtc gacgaatacc
     5521 acagctacgc ccccgaggcc gcccggcccg tacgcctgat ctggctggcc gcccaccgcg
     5581 accacgccac gttcaccagc gccgccgacc tcgactacga caccctgctc cgcaccgaac
     5641 tgggcgaggc gacgctggcc cggttcgccg agaccatggc cgccctcgac ctggacctgg
     5701 ccgactacct gctcatcccg gtgcacccct ggcagtggtg gaacaagctg tcggtgacct
     5761 tcgccggtga ggtggcccgc cgccgcctgg tgcacctcgg cgagagcgac gacgactacc
     5821 tcgcccagca gtccatccgc accttcttca acgtcagcgc gccgcaccgg cactacgtca
     5881 agacgtcgct gtcggtgctg aacatgggct tcatgcgagg gttgtcggcg gcgtacatgg
     5941 aagccacccc ggccatcaac gactggctgg ccgatctgat caccgccgac gaggtgttcc
     6001 aggccaccgg cctgacgatc atccgggagc gggccgccgt cggctaccgc aaccggcagt
     6061 acgaagccgc caccgaccgc tactcgccgt accgcaagat gcttgccgcg ctgtggcggg
     6121 agagcccggt gcccaccctg gcccccggcg aacggctggc caccatggcc tcgctgctgc
     6181 acgtcgacgc cgacggccgg tccttcgccg ccgaactgat caccgcctcc gggctggcac
     6241 cggcgcaatg gctacgccgc tacctgcacg cctacctcac cccgctgctg cacgccttct
     6301 acgcctacga cctggcgttc atgccgcacg gcgagaacgt catcctggtg ctgcgcgacc
     6361 acgccgtaca acgggtgatc ttcaaggaca tcgccgagga gatcgtggtg atgaacaccg
     6421 aggcggccct gcccccggcg gtcgaacgga tccgcgccga ggtgccggag gagatgaaac
     6481 tgctgtccat cttcaccgac gtcttcgact gcttcttccg cttcctcggc gccaccctcg
     6541 ccgaccaggg catcgccgac gaggagacct tctggcgtac ggtcgccgac tgcgccaccg
     6601 actacgccgc ccgggtacca cacctggccg accggctggc ccgctacgac ctgttcgccc
     6661 ccgagttcgc cctgtcctgc ctcaaccggc tgcaactgcg cgacaaccag cagatggtcg
     6721 acctggccga cccgtcggcc gccctgcagc tcgtcggcgc cctcaccaac cccctggccc
     6781 ggcacgcacc ctcctgaccc gccaccgacg ctcacctgtc cgtgcccgcc gatgaaacat
     6841 gtccgcggat ggaccatgtc cgccgatgga acatatccgc cgatggaaca tgtcggcaga
     6901 catggaactc gtcggcggcc acggacaggt acaggtgtga cagcacagtt gcggcgtcgg
     6961 atccgagccg gcgacaccga cgcctttggt gaactcttcg acgagcatgc cgacgcggtc
     7021 caccgccatg cggtgtggag cgagggcgac ccggtgctcg ccgaggacgt ggtgtcgctg
     7081 accttcctcg aggcgtggcg gatccgggag tcgcttcgac cggacgggga gagcctgcgg
     7141 ccctggctgc tcggcatcgc cacaaacgtg ctgcgtaacc ggcggcgggc ggcgcgccgg
     7201 caccgggcgg cgctacggcg gctgccggta cgcgacacgg tgccggactt cgccgacgac
     7261 gtggtcggcc ggatgcacga cgccgaccag ctcgccgccg ccgtggcggc cctgcgggcc
     7321 ctgcgtcggg cggaccggga ggtgttcctg ctgtgcgtct ggtcgcagct ggactacgcg
     7381 gcagcagccg aagccctggg ggttcccgtc gggaccgtgc gttcgcggct gtcccgggcc
     7441 cgaacccggc tgcgggcgct ggcccagcag gaactggacc gtccgcgagg cacccccgtc
     7501 gagcagggag agtaccgatg agcgagccga ctgttccgca cgtgccggcg atggccaccg
     7561 cgcaccggca ggccctgcgc cggcacctga tgaacgagat cacccggccg gcccggcggc
     7621 cgaagcggac gccggtgctc gcgggcgcgg tgggcgtact ggccgcggtg atcgcggccg
     7681 ggacgatcgc gctgcccggg gtgccgcaga gcgcgccgct tgtcgtaact gtgcaacagg
     7741 cggaaccggc ggccgcgacg acattgctga acgcgatggc cgctgccgtc gtcgagaagc
     7801 cggaaccggg cgacgggagg tacgtctaca tcaggagcct gggcgcctac gccgaactgg
     7861 gtggcggtcc ggcccggctg cgaccggtac gcgagcggga gatctggatc ccccggtacg
     7921 agccgggcga tggtctgctc cgacagccgt tcttcgaact gccggtcatc ggcgtgatcc
     7981 ccgagcgggt gacgctgacg gacatgacgc cgaacgcggc ggtcgtcgat ctgcccgacg
     8041 acccggatga actgctggcc aagctctacc gggaacgtgc cgagcggggc cacggcagca
     8101 gccgcgacgg cgcggcgttc accgcgatcg gcgacatcct gcgggaatcg ctggtgccgc
     8161 cacagacaag cgccgctcta taccgggccg cagcccggat tcccggagtc gaggtgatcc
     8221 gtcaggtgac cgacgcggcg ggccggcggg ggaccgccgt cgcgtacacc gaacgggacc
     8281 gccgcgacga gtggatcttc gatgagcgga ccttcgagta cctcggctcg cgtagctacc
     8341 tcgtggcgga cactgccgat ggaccggccg gcaccgtgct ggccaccact gccgtgctgc
     8401 aacgtgccgt ggtgccgaag ctcgggcagc gtccgtgatc acgcgccgcg cacagcggcc
     8461 gggcactcgg cggccggtta ctcggcgctc aggtccgcta ggtcgcggtc gagtagctcg
     8521 gcgagcaggg tgtgtcggcc ggggtcgttg tcgacggtga tgccccggct gggcatctcc
     8581 acggtcatca gcaggtgcag gtgcatccgg tacaacgcca accggcggcg tacccggtcg
     8641 tcgaagacca gcggcgtgcc gacggcgtcg gcgtagccgt gcaggaacgg atgctccggc
     8701 tcgtcctcgg cgcgccggaa cagcaggggc gagaccaggt ccagcatcgg gtcgccgtag
     8761 aggaaccgtt cgccgtcgac aagcccgcac atccggtacg ccccgtgcgc gtcgggcgcg
     8821 gccagcacgt tgccgtccca gccgtcgaag tgcagcaggg cgggtcggcg cacctggtcg
     8881 agcaggccgg cgtgccgggc caccacctcc cggaaccgct gcggcggcgc gggaagtgtg
     8941 acgttccagt cgaccgcgtc ggcgagcaga tcgtcgacga tcgccgcgaa cgccaccgac
     9001 caggtaatgc cgccggcacg gccggcgtcg tagccgaacc ggtcaccggt gatccggtgc
     9061 agggtggcca ccgtcgcccc gaagtcgtag cgtgcgcccg cgtcggcacc gtccaggtcg
     9121 ggcagcgccc ggccgggcag ccgaccagtg accagccact cgccgagacg ggcgtcgcga
     9181 ccgtggtgca gcaccggcgg caccggcacc tgcggggccc gggcggcgac cagccggaag
     9241 taacgggcct cggcggcgag catcccggtc tcgtagcgca gcagcggcac gtgcgacggt
     9301 ggcccgacct tgaggacgac gtctgcgccg tcgtcgaggc gcacccacca gacggtggcg
     9361 aacccgccgc cggtcagcgg cccgcagtcg gcgacctgcc ggtccgcgcc gaacgaggcg
     9421 gcgatgtagt cggccacgtc gtcgggggag aggacctgct gggtggggct cagcggtggc
     9481 accggcacag ggtatccgta ccggtgccac cgcggcgtcc ccgctcagcc gtcggtcacc
     9541 acaccggtca gcaccggcgg cagctgcggc ccgtccggct cctggtcgaa gcgcagctcg
     9601 atccactcgt ccggctcgac caccgagtcg gtgatcgtcg ggacggtgat ctcagcgacg
     9661 accgcgtccg gggccaggtc caggtacggc accagccagg tctgggacag cggccgttcg
     9721 ggctccaccg gcgagtacgc gtgctcggtg aaccagtccg gatcgacgtc catggtggac
     9781 agctcgggac cgtcggtcgg cggctgcggc caggcgatgg cgaagatgcc ctgttccgtc
     9841 ggcgcggacg aggtgaaacg ccaggtcaac gtctcgcctt cggtgacgcg ctggacgggt
     9901 tcgacagtga tggtcggcgc cggatcgtcg ttgagcacgt cgagaccgcc gaggtagctg
     9961 ccgaccacca tgccctgctg cgccttggcg gtcagcaggt accgctcggt gtagttccac
    10021 agcgtgtcac cgaccacctc ggccggcacc cggatgctgc gctgaccggg ccggacggtg
    10081 gccagccagg agcggctgac gaacatgtca tcggtcaggt tcagctgtac tgtcgcgctg
    10141 ccgcgtcccg tgatggtcgc cgggatctcg tacgtcttcg tgccggagtc accctcggcc
    10201 acctccaagg tgccgatgtc gagccgcagc aggcgggggg cacgcgggtc gggggtgccc
    10261 ggcttccagc cccacgcgtc gagcagccat gcctgcccga acgcggtgcg tggcgtgacc
    10321 tcgatggcgg ccagtcgagc gggtgccccc ttcaacggca cccgcacctc ctgcgcccag
    10381 tgcgaggtcg tgttgccggt gccgggcaga ccgtcgatgc gtacctcgcc cagccggctg
    10441 cgccgcccgt cggtgccgac gactgtcacg tcgaaccggg tgtcggtcgt gttcggcgcg
    10501 acgatgatcc gcagcgccag gtcacgggcg ccggcgacgg aaaccggccg ggccggagcc
    10561 agccggatcg gtgtgccggc acgggaccag gccagctcgg ccgcgtaccg gttgggctcg
    10621 gggatggtcc agaggaaggg cgtgaagtgt gcgaggaaag cgttgcgatc catcgggtcg
    10681 aggcaggacc gctcggcgtc gtcggtgacc tggtcgcaga tccgggcacc acccgacagc
    10741 tgtgtcgacg cgtccggggt gagcaccggc gtgcggttgc cgccgagggc gtgggcgagc
    10801 acccgcgccg ggtcggccga gggtgcccgt cggccggtgc cgtcgagcag cggccggatc
    10861 cggtcgtcac cttcgacgaa gagccgcgcg gcggcggcga tgtaggtggc gccgacggtc
    10921 tgctgctggt tggcggtgag ccggctcggc atgcccggtg aacagaccag gtccggctcg
    10981 tcgtctctgg tgtagaagtc gtcctgggac ggtgccaccg actgtccggg cgtccattcg
    11041 gtgttgaagt agttgtggtt ggccccgatc acgtacagcg cgctgcgcag tgcgcgactc
    11101 gggctgagtc cgcgcgtggc gtcgacgaac atctggccct gcaggtcgaa gacgtcaccg
    11161 tcgcagccgg gcaggatggt caccgacggg acgtccggca ccgggttgtg cccgaagagc
    11221 gtgggaccga tcagcagcat gccgcgtacg gtccagcgaa ctgtgccggg gtagccgtcc
    11281 tgggccctcg gcggtggggt gagtgagtcc atcgccgccc ggctgacccc ctcgccacca
    11341 cgggagtgac ccatcaggaa cacctgggac aggtcggccc ggggcgcggc ccgcacgatg
    11401 ctcggcgctg cggcacgacc cgtgcgggcc cagtcggccc acttcgccag gtgcagccgt
    11461 acgagcgagg agcgggcctg ggcaccgccg tcggcggcgg cccagtcctg accgttgatg
    11521 ccgttggccg agatggacac ggtcacgtag ccctgcgagg cgagcagccg ctgcgcctgc
    11581 aggtagccac ggtggctcgg gatcggatcg gtgccggccg ggcacggcca ctgctggggc
    11641 acctgctcgt cgccccggta gcagacggcg tggcgaccgt gcaggaacag cgccagtggc
    11701 cgggcgccgg tggtgccctg cggcgcgacc accaccgccc gcatctcgac cttctccggg
    11761 aactccggca gggtgacccc gggaaggtcg tactccc
//
